NPC 567 | CAS# 109333-26-8 | Bradykinin Receptor Antagonist

MedKoo Cat#: 573264 | Name: NPC 567

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NPC 567 is a bradykinin receptor antagonist.

Chemical Structure

NPC 567

CAS#109333-26-8

Theoretical Analysis

MedKoo Cat#: 573264

Name: NPC 567

CAS#: 109333-26-8

Chemical Formula: C60H87N19O13

Exact Mass: 1281.6731

Molecular Weight: 1282.48

Elemental Analysis: C, 56.19; H, 6.84; N, 20.75; O, 16.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

NPC 567

IUPAC/Chemical Name

((2S,4R)-1-(D-arginyl-L-arginyl-L-prolyl)-4-hydroxypyrrolidine-2-carbonyl)glycyl-L-phenylalanyl-L-seryl-D-phenylalanyl-L-phenylalanyl-L-arginine

InChi Key

RBIXVHPHNGXTCI-QJTYZATASA-N

InChi Code

1S/C60H87N19O13/c61-39(20-10-24-68-58(62)63)49(83)73-40(21-11-25-69-59(64)65)55(89)78-27-13-23-46(78)56(90)79-33-38(81)31-47(79)54(88)71-32-48(82)72-42(28-35-14-4-1-5-15-35)50(84)77-45(34-80)53(87)76-44(30-37-18-8-3-9-19-37)52(86)75-43(29-36-16-6-2-7-17-36)51(85)74-41(57(91)92)22-12-26-70-60(66)67/h1-9,14-19,38-47,80-81H,10-13,20-34,61H2,(H,71,88)(H,72,82)(H,73,83)(H,74,85)(H,75,86)(H,76,87)(H,77,84)(H,91,92)(H4,62,63,68)(H4,64,65,69)(H4,66,67,70)/t38-,39-,40+,41+,42+,43+,44-,45+,46+,47+/m1/s1

SMILES Code

C1[C@H](O)C[C@H](C(NCC(=O)N[C@@H](Cc2ccccc2)C(N[C@@H](CO)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)N1C([C@@H]1CCCN1C([C@H](CCCNC(N)=N)NC(=O)[C@H](N)CCCNC(N)=N)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,282.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sylvin H, van der Ploeg I, Alving K. The effect of a bradykinin B2 receptor antagonist, NPC-567, on allergen-induced airway responses in a porcine model. Inflamm Res. 2001 Sep;50(9):453-9. PubMed PMID: 11603850. 2: Higgins PG, Barrow GI, Tyrrell DA. A study of the efficacy of the bradykinin antagonist, NPC 567, in rhinovirus infections in human volunteers. Antiviral Res. 1990 Dec;14(6):339-44. PubMed PMID: 1965113.

View History

Description:

Chemical Structure

Theoretical Analysis

Price and Availability

Preparing Stock Solutions

View History

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