Synonym
Lysine theophylline
IUPAC/Chemical Name
L-Lysine, compd. with 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (1:1)
InChi Key
UBLVUWUKNHKCJJ-ZSCHJXSPSA-N
InChi Code
InChI=1S/C7H8N4O2.C6H14N2O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;7-4-2-1-3-5(8)6(9)10/h3H,1-2H3,(H,8,9);5H,1-4,7-8H2,(H,9,10)/t;5-/m.0/s1
SMILES Code
N[C@@H](CCCCN)C(O)=O.O=C(N1C)N(C)C2=C(NC=N2)C1=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
326.36
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Jackson SH, Shah K, Debbas NM, Johnston A, Peverel-Cooper CA, Turner P. The interaction between i.v. theophylline and chronic oral dosing with slow release nifedipine in volunteers. Br J Clin Pharmacol. 1986 Apr;21(4):389-92. PubMed PMID: 3707813; PubMed Central PMCID: PMC1400949.
2: Jackson SH, Wiffen JK, Johnston A, Peverel-Cooper CA. The relationship between clearance of theophylline and age within the adult age range. Eur J Clin Pharmacol. 1985;29(2):177-9. PubMed PMID: 3908122.
3: Jiang CS, Kilfeather SA, Pearson RM, Turner P. The stimulatory effects of caffeine, theophylline, lysine-theophylline and 3-isobutyl-1-methylxanthine on human sperm motility. Br J Clin Pharmacol. 1984 Aug;18(2):258-62. PubMed PMID: 6207849; PubMed Central PMCID: PMC1463533.
4: Jackson SH, Wiffen JK, Johnston A, Peverel-Cooper CA. The disposition of inhaled lysine theophylline in volunteers. Eur J Clin Pharmacol. 1984;26(5):635-7. PubMed PMID: 6468482.
5: Johnston A, Aldhous ME, Hedges A, Weerasuriya K, Freedman A, Turner P. The pharmacokinetics of lysine theophylline, a new soluble theophylline, in human volunteers. Postgrad Med J. 1983 Feb;59(688):86-7. PubMed PMID: 6844192; PubMed Central PMCID: PMC2417382.
