Swertianin | CAS#20882-75-1 | xanthone

MedKoo Cat#: 146216 | Name: Swertianin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Swertianin is a naturally occurring xanthone compound isolated from plants of the Swertia genus, commonly used in traditional medicine. It is known for its diverse biological activities, including antioxidant, anti-inflammatory, and potential antidiabetic effects. The mechanism of action of swertianin is believed to involve modulation of oxidative stress pathways, inhibition of pro-inflammatory enzymes, and possible enhancement of insulin sensitivity. Applications of swertianin are primarily in pharmacological research, particularly for developing therapies targeting metabolic disorders and inflammatory conditions.

Chemical Structure

Swertianin

CAS#20882-75-1

Theoretical Analysis

MedKoo Cat#: 146216

Name: Swertianin

CAS#: 20882-75-1

Chemical Formula: C14H10O6

Exact Mass: 274.0477

Molecular Weight: 274.23

Elemental Analysis: C, 61.32; H, 3.68; O, 35.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Swertianin; Swertianine;

IUPAC/Chemical Name

1,2,8-trihydroxy-6-methoxy-9H-xanthen-9-one

InChi Key

BDBVOZGRVBXANN-UHFFFAOYSA-N

InChi Code

1S/C14H10O6/c1-19-6-4-8(16)11-10(5-6)20-9-3-2-7(15)13(17)12(9)14(11)18/h2-5,15-17H,1H3

SMILES Code

COC1=CC2=C(C(=O)C3=C(O2)C=CC(O)=C3O)C(O)=C1

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 274.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cao C, Hu B, Wang J, Li W, Guo L, Sheng J, Zhang C. Swertianin Promotes Anti- Tumor activity by facilitating Macrophage M1 polarization via STING signaling. Int Immunopharmacol. 2024 Dec 5;142(Pt B):113182. doi: 10.1016/j.intimp.2024.113182. Epub 2024 Sep 18. PMID: 39298821. 2: Singh PP, Ambika, Chauhan SM. Activity-guided isolation of antioxidant xanthones from Swertia chirayita (Roxb.) H. Karsten (Gentianaceae). Nat Prod Res. 2012;26(18):1682-6. doi: 10.1080/14786419.2011.592836. Epub 2011 Oct 10. PMID: 21985644. 3: Mahendran G, Thamotharan G, Sengottuvelu S, Bai VN. Evaluation of anticonvulsant, sedative, anxiolytic, and phytochemical profile of the methanol extract from the aerial parts of Swertia corymbosa (Griseb.) wight ex C.B. Clarke. Biomed Res Int. 2014;2014:542385. doi: 10.1155/2014/542385. Epub 2014 Apr 27. PMID: 24877112; PMCID: PMC4022199. 4: Mahendran G, Thamotharan G, Sengottuvelu S, Narmatha Bai V. RETRACTED: Anti- diabetic activity of Swertia corymbosa (Griseb.) Wight ex C.B. Clarke aerial parts extract in streptozotocin induced diabetic rats. J Ethnopharmacol. 2014 Feb 12;151(3):1175-1183. doi: 10.1016/j.jep.2013.12.032. Epub 2013 Dec 27. Retraction in: J Ethnopharmacol. 2017 Jul 31;207:271. doi: 10.1016/j.jep.2017.06.049. PMID: 24378350. 5: Qing Z, Jiachun C, Yanwen L. [Study on chemical constituents from Swertia kauitchensis Franch]. Zhong Yao Cai. 2004 Dec;27(12):908-10. Chinese. PMID: 15807240.