Lys-ala-NH-MEC | CAS#94149-28-7

MedKoo Cat#: 530711 | Name: Lys-ala-NH-MEC

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lys-ala-NH-mec, also known as 7-Lysylalanyl-4-methylcoumarinamide, is a Fluorogenic substrate for dipeptidyl aminopeptidase.

Chemical Structure

Lys-ala-NH-MEC

CAS#94149-28-7

Theoretical Analysis

MedKoo Cat#: 530711

Name: Lys-ala-NH-MEC

CAS#: 94149-28-7

Chemical Formula: C19H26N4O4

Exact Mass: 374.1954

Molecular Weight: 374.44

Elemental Analysis: C, 60.95; H, 7.00; N, 14.96; O, 17.09

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

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Synonym

7-Lysylalanyl-4-methylcoumarinamide; 7-Lys-ala-4-mca; Lys-ala-NH-mec;

IUPAC/Chemical Name

L-Alaninamide, L-lysyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

InChi Key

VSRJZLOPKBZWMF-WFASDCNBSA-N

InChi Code

InChI=1S/C19H26N4O4/c1-11-9-17(24)27-16-10-13(6-7-14(11)16)23(12(2)18(22)25)19(26)15(21)5-3-4-8-20/h6-7,9-10,12,15H,3-5,8,20-21H2,1-2H3,(H2,22,25)/t12-,15-/m0/s1

SMILES Code

C[C@@H](C(N)=O)N(C([C@H](CCCCN)N)=O)C1=CC=C(C(O2)=C1)C(C)=CC2=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 374.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Chung J, Ulyanov NB, Guilbert C, Mujeeb A, James TL. Binding characteristics of small molecules that mimic nucleocapsid protein-induced maturation of stem-loop 1 of HIV-1 RNA. Biochemistry. 2010 Aug 3;49(30):6341-51. doi: 10.1021/bi100660r. PubMed PMID: 20565056; PubMed Central PMCID: PMC2921804. 2: Smid JR, Young WG, Monsour PA. Dipeptidyl-peptidase II and cathepsin B activities in amelogenesis of the rat incisor. Eur J Oral Sci. 2001 Aug;109(4):260-6. PubMed PMID: 11531072. 3: Cox SW, Gazi MI, Eley BM. Dipeptidyl peptidase II- and IV-like activities in gingival tissue and crevicular fluid from human periodontitis lesions. Arch Oral Biol. 1992 Mar;37(3):167-73. PubMed PMID: 1350193. 4: Smyth M, O'Connor B, O'Cuinn G. Subcellular distribution of dipeptidyl aminopeptidase activity against Lys-Ala-NH-Mec in guinea-pig brain. Biochem Soc Trans. 1991 Feb;19(1):37S. PubMed PMID: 2037170. 5: Nagatsu T, Sakai T, Kojima K, Araki E, Sakakibara S, Fukasawa K, Harada M. A sensitive and specific assay for dipeptidyl-aminopeptidase II in serum and tissues by liquid chromatography-fluorometry. Anal Biochem. 1985 May 15;147(1):80-5. PubMed PMID: 3896025.