D-Biotin-PEG6-Thalidomide is a cereblon affinity probe for PROTAC and targeted protein degradation research. It can be used in cereblon (CRBN) binding and displacement assays for protein degrader validation experiments, CRBN ligand discovery, competition analyses, or where enrichment of CRBN complexes is required. The hydrophilic PEG spacer increases the solubility of a compound in aqueous media.
MedKoo Cat#: 122088
Name: D-Biotin-PEG6-Thalidomide
CAS#: 2144775-48-2
Chemical Formula: C37H53N5O12S
Exact Mass: 791.3411
Molecular Weight: 791.91
Elemental Analysis: C, 56.12; H, 6.75; N, 8.84; O, 24.24; S, 4.05
The following data is based on the product molecular weight 791.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
