Isoaminile | CAS# 77-51-0 | Antitussive

MedKoo Cat#: 573202 | Name: Isoaminile

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isoaminile is an antitussive (cough suppressant) used under the trade-name Peracon. In addition to its antitussive effects, it is also an anticholinergic, exhibiting both antimuscarinic and antinicotinic actions.

Chemical Structure

Isoaminile

CAS#77-51-0

Theoretical Analysis

MedKoo Cat#: 573202

Name: Isoaminile

CAS#: 77-51-0

Chemical Formula: C16H24N2

Exact Mass: 244.1939

Molecular Weight: 244.38

Elemental Analysis: C, 78.64; H, 9.90; N, 11.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Aprecon, Isoaminil, Isoaminile, Nullatuss, Peracon

IUPAC/Chemical Name

4-(Dimethylamino)-2-isopropyl-2-phenylvaleronitrile

InChi Key

WFLSCFISQHLEED-UHFFFAOYSA-N

InChi Code

1S/C16H24N2/c1-13(2)16(12-17,11-14(3)18(4)5)15-9-7-6-8-10-15/h6-10,13-14H,11H2,1-5H3

SMILES Code

c1([C@@](C[C@@H](N(C)C)C)(C(C)C)C#N)ccccc1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

The normal therapeutic dose is 40–80 mg of the cyclamate salt, with a maximum of five doses in a 24-hour period.

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 244.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Diwan J, Dhand R, Jindal SK, Malik SK, Sharma PL. A comparative randomized double-blind clinical trial of isoaminile citrate and chlophedianol hydrochloride as antitussive agents. Int J Clin Pharmacol Ther Toxicol. 1982 Aug;20(8):373-5. PubMed PMID: 6749701. 2: Marigo M, Ferrara SD, Cima L, Giusti P, Floreani M. Some cases of acute intoxications from compulsive use of isoaminile. Arch Toxicol. 1979 Sep;42(4):295-301. PubMed PMID: 518294. 3: Bastos WP, Ramos AO. Isoaminile as inhibitor of muscarinic and nicotinic ganglionic receptors. Pharmacology. 1970;4(1):39-44. PubMed PMID: 5431771. 4: GRAHAM JD. Evaluation of isoaminile citrate as an antitussive. J New Drugs. 1962 Jan-Feb;2:43-9. PubMed PMID: 13901029. 5: BRENNER-GOEDDERZ L. [Peracon in practice. Experiences with a new kind of antitussive agent]. Med Klin. 1959 Oct 30;54:2004-6. German. PubMed PMID: 13804201.