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MedKoo Cat#: 564642 | Name: Bisleuconothine A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bisleuconothine A is a selective Wnt signaling inhibitor.

Chemical Structure

Bisleuconothine A
Bisleuconothine A
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564642

Name: Bisleuconothine A

CAS#: NONE

Chemical Formula: C38H48N4O

Exact Mass: 576.3828

Molecular Weight: 576.83

Elemental Analysis: C, 79.13; H, 8.39; N, 9.71; O, 2.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Bisleuconothine A
IUPAC/Chemical Name
(3aR,3a1R,5aR,10bR)-3a-ethyl-7-((41R,12S,13aR)-13a-ethyl-2,3,41,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12-yl)-2,3,3a,3a1,4,5,5a,6,11,12-decahydro-1H-indolizino[8,1-cd]carbazol-10-ol
InChi Key
HHCOPHVLECRPRE-UQYJQATHSA-N
InChi Code
InChI=1S/C38H48N4O/c1-3-36-15-7-20-41-22-18-38(35(36)41)30(13-17-36)39-32-26(11-12-29(43)31(32)38)28-23-37(4-2)16-8-19-40-21-14-25-24-9-5-6-10-27(24)42(28)33(25)34(37)40/h5-6,9-12,28,30,34-35,39,43H,3-4,7-8,13-23H2,1-2H3/t28-,30+,34-,35+,36+,37+,38-/m0/s1
SMILES Code
OC1=CC=C([C@H]2N3C4=C(C5=C3C=CC=C5)CCN6[C@]4([H])[C@@](CCC6)(CC)C2)C7=C1[C@@]8(CCN9CCC%10)[C@@]9([H])[C@@]%10(CC)CC[C@@]8([H])N7
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 576.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kong LM, Feng T, Wang YY, Li XY, Ye ZN, An T, Qing C, Luo XD, Li Y. Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell in vitro and in vivo targeting Wnt signaling. Oncotarget. 2016 Mar 1;7(9):10203-14. doi: 10.18632/oncotarget.7190. PubMed PMID: 26862734; PubMed Central PMCID: PMC4891114. 2: Wong CP, Seki A, Horiguchi K, Shoji T, Arai T, Nugroho AE, Hirasawa Y, Sato F, Kaneda T, Morita H. Bisleuconothine A Induces Autophagosome Formation by Interfering with AKT-mTOR Signaling Pathway. J Nat Prod. 2015 Jul 24;78(7):1656-62. doi: 10.1021/acs.jnatprod.5b00258. Epub 2015 Jul 15. PubMed PMID: 26176165. 3: Liu L, Cao JX, Yao YC, Xu SP. Progress of pharmacological studies on alkaloids from Apocynaceae. J Asian Nat Prod Res. 2013;15(2):166-84. doi: 10.1080/10286020.2012.747521. Epub 2012 Dec 19. Review. PubMed PMID: 23249181. 4: Hirasawa Y, Shoji T, Arai T, Nugroho AE, Deguchi J, Hosoya T, Uchiyama N, Goda Y, Awang K, Hadi AH, Shiro M, Morita H. Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii. Bioorg Med Chem Lett. 2010 Mar 15;20(6):2021-4. doi: 10.1016/j.bmcl.2010.01.051. Epub 2010 Jan 20. PubMed PMID: 20153644.