PF-06445974 a promising PET lead. PF-06445974 has exquisite potency at PDE4B, good selectivity over PDE4D, excellent brain permeability, and a high level of specific binding in the “cold tracer” study. In subsequent non-human primate (NHP) PET imaging studies, [18F]PF-06445974 showed rapid brain uptake and high target specificity, indicating that [18F]PF-06445974 is a promising PDE4B-preferring radioligand for clinical PET imaging.
MedKoo Cat#: 530957
Name: PF-06445974
CAS#: 2055776-17-3
Chemical Formula: C20H15FN4O
Exact Mass: 346.1230
Molecular Weight: 346.37
Elemental Analysis: C, 69.35; H, 4.37; F, 5.49; N, 16.18; O, 4.62
The following data is based on the product molecular weight 346.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
