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MedKoo Cat#: 564640 | Name: D2923

Description:

WARNING: This product is for research use only, not for human or veterinary use.

D2923 is a selective inhibitor of colony-stimulating factor 1 receptor (CSF1R).

Chemical Structure

D2923
D2923
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564640

Name: D2923

CAS#: NONE

Chemical Formula: C31H36Cl2N8O2

Exact Mass: 622.2338

Molecular Weight: 623.58

Elemental Analysis: C, 59.71; H, 5.82; Cl, 11.37; N, 17.97; O, 5.13

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
D-2923; D 2923; D2923
IUPAC/Chemical Name
(S)-3-(2,6-Dichlorophenyl)-7-((3-methyl-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-(1-propionylpyrrolidin-3-yl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one
InChi Key
UAEJGNXQHGHNAP-QHCPKHFHSA-N
InChi Code
InChI=1S/C31H36Cl2N8O2/c1-4-27(42)39-11-10-23(19-39)41-29-21(18-40(31(41)43)28-24(32)6-5-7-25(28)33)17-34-30(36-29)35-22-8-9-26(20(2)16-22)38-14-12-37(3)13-15-38/h5-9,16-17,23H,4,10-15,18-19H2,1-3H3,(H,34,35,36)/t23-/m0/s1
SMILES Code
O=C1N([C@@H]2CN(C(CC)=O)CC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C(C)=C4)=NC=C3CN1C6=C(Cl)C=CC=C6Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 623.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu YQ, Wang YN, Lu XY, Tong LJ, Li Y, Zhang T, Xun QJ, Feng F, Chen YZ, Su Y, Shen YY, Chen Y, Geng MY, Ding K, Li YL, Xie H, Ding J. Identification of compound D2923 as a novel anti-tumor agent targeting CSF1R. Acta Pharmacol Sin. 2018 Nov;39(11):1768-1776. doi: 10.1038/s41401-018-0056-0. Epub 2018 Jul 3. PubMed PMID: 29968849; PubMed Central PMCID: PMC6289367.