NBTI-5463 is a bacterial type II topoisomerase inhibitor. NBTI 5463 demonstrated promising activity against a broad range of Gram-negative pathogens. In studies with P. aeruginosa, NBTI 5463 was bactericidal. Resistant mutants arose at a low rate, and the mutations were found exclusively in the nfxB gene, a regulator of the MexCD-OprJ efflux system. Levofloxacin-selected resistance mutations in GyrA did not result in decreased susceptibility to NBTI 5463. Animal infection studies demonstrated that NBTI 5463 was efficacious in mouse models of lung, thigh, and ascending urinary tract infections.
MedKoo Cat#: 564594
Name: NBTI-5463
CAS#: 1227303-03-8
Chemical Formula: C25H30N6O4
Exact Mass: 478.2329
Molecular Weight: 478.55
Elemental Analysis: C, 62.75; H, 6.32; N, 17.56; O, 13.37
The following data is based on the product molecular weight 478.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
