MedKoo Cat#: 562521 | Name: GSK106 HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK106 is a negative control compound used in binding and functional assays for PAD4 inhibitors.

Chemical Structure

GSK106 HCl
GSK106 HCl
CAS#1652591-82-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 562521

Name: GSK106 HCl

CAS#: 1652591-82-6 (HCl)

Chemical Formula: C24H28ClN5O

Exact Mass: 437.1982

Molecular Weight: 437.97

Elemental Analysis: C, 65.82; H, 6.44; Cl, 8.09; N, 15.99; O, 3.65

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
100mg USD 1,250.00 2 Weeks
1g USD 4,650.00 2 Weeks
2g USD 6,450.00 2 Weeks
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Related CAS #
1652591-82-6 (HCl) 1652629-24-7 (free base)
Synonym
GSK106; GSK-106; GSK 106;
IUPAC/Chemical Name
(3-Aminopiperidin-1-yl)(2-(1-ethyl-1H-indol-2-yl)-1-methyl-1H-benzo[d]imidazol-6-yl)methanone hydrochloride
InChi Key
VRPFLFUQMWOJAT-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H27N5O.ClH/c1-3-29-20-9-5-4-7-16(20)13-22(29)23-26-19-11-10-17(14-21(19)27(23)2)24(30)28-12-6-8-18(25)15-28;/h4-5,7,9-11,13-14,18H,3,6,8,12,15,25H2,1-2H3;1H
SMILES Code
O=C(N1CC(N)CCC1)C2=CC=C3C(N(C)C(C(N4CC)=CC5=C4C=CC=C5)=N3)=C2.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 437.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jones, J.E., Causey, C.P., Knuckley, B., et al. Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential. Curr. Opin. Drug Discov. Devel. 12(5), 616-627 (2009). 2: Lewis, H.D., Liddle, J., Coote, J.E., et al. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat. Chem. Biol. 11(3), 189-191 (2015).