MedKoo Cat#: 584717 | Name: Mf 268

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mf 268 is a pseudo-reversible carbamate-type inhibitor which interacts with the catalytic and regulatory anionic site of the enzyme.

Chemical Structure

Mf 268
Mf 268
CAS#154619-51-9

Theoretical Analysis

MedKoo Cat#: 584717

Name: Mf 268

CAS#: 154619-51-9

Chemical Formula: C19H18F2N8OS

Exact Mass: 444.1292

Molecular Weight: 444.46

Elemental Analysis: C, 51.34; H, 4.08; F, 8.55; N, 25.21; O, 3.60; S, 7.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Mf 268; Mf-268
IUPAC/Chemical Name
Carbamic acid, (8-(2,6-dimethyl-4-morpholinyl)octyl)-, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-yl ester, (3aS-(3a-alpha,5(2R*,6S*),8a-alpha))-
InChi Key
ICRBJWBMXZYUGP-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H18F2N8OS/c1-18(2,31-17-6-5-16(26-27-17)29-12-23-10-25-29)19(30,8-28-11-22-9-24-28)14-4-3-13(20)7-15(14)21/h3-7,9-12,30H,8H2,1-2H3
SMILES Code
OC(C(SC1=NN=C(N2N=CN=C2)C=C1)(C)C)(C3=CC=C(F)C=C3F)CN4N=CN=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 444.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhu XD, Cuadra G, Brufani M, Maggi T, Pagella PG, Williams E, Giacobini E. Effects of MF-268, a new cholinesterase inhibitor, on acetylcholine and biogenic amines in rat cortex. J Neurosci Res. 1996 Jan 1;43(1):120-6. PubMed PMID: 8838583. 2: Bartolucci C, Perola E, Cellai L, Brufani M, Lamba D. "Back door" opening implied by the crystal structure of a carbamoylated acetylcholinesterase. Biochemistry. 1999 May 4;38(18):5714-9. PubMed PMID: 10231521. 3: Braida D, Paladini E, Griffini P, Lamperti M, Colibretti L, Sala M. Long-lasting antiamnesic effect of a novel anticholinesterase inhibitor (MF268). Pharmacol Biochem Behav. 1998 Apr;59(4):897-901. PubMed PMID: 9586846.