Lincomycin hydrochloride anhydrous | CAS# 859-18-7 | Antibiotic

MedKoo Cat#: 573181 | Name: Lincomycin hydrochloride anhydrous

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lincomycin hydrochloride anhydrous is an antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.

Chemical Structure

Lincomycin hydrochloride anhydrous

CAS#859-18-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 573181

Name: Lincomycin hydrochloride anhydrous

CAS#: 859-18-7 (HCl)

Chemical Formula: C18H35ClN2O6S

Exact Mass: 442.1904

Molecular Weight: 444.00

Elemental Analysis: C, 48.80; H, 7.96; Cl, 8.00; N, 6.32; O, 21.67; S, 7.24

Price and Availability

Size	Price	Availability	Quantity
1g	USD 350.00	2 Weeks
5g	USD 950.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

7179-49-9 (HCl hydrate) 859-18-7 (HCl) 154-21-2

Synonym

Antibiotic 124a HCl, Lincomycin HCl, Lincomycin hydrochloride anhydrous, Mycivin

IUPAC/Chemical Name

(2S,4R)-N-((1R,2R)-2-hydroxy-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide hydrochloride

InChi Key

POUMFISTNHIPTI-BOMBIWCESA-N

InChi Code

1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1

SMILES Code

CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@@H](C)O.Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Lincomycin Hydrochloride(U10149A) is an antibiotic produced by Streptomyces lincolnensis var.

In vitro activity:

Treatment with LM (lincomycin) or LM + DX (dexamethasone) stimulated proliferation of melanoma cells with minimal cytotoxicity, while DX did not influence cell proliferation either alone or in combination with LM. Treatment with LM alone increased tyrosinase activity slightly and reduced melanin content in a dose-dependent manner. However, LM counteracted the pronounced increase in tyrosinase elicited by DX and also abrogated the dose-dependent increase in melanin content elicited by DX. Reference: Pigment Cell Res. 1998 Jun;11(3):143-50. https://pubmed.ncbi.nlm.nih.gov/9730321/

In vivo activity:

Lincomycin (LCM), imipenem (IPM), cilastatine (CS), and ampicillin (ABPC) were used for antibiotics treatment. The survival rate of SPG/IND-treated mice was significantly increased by administering LCM or ABPC/IPM/CS, and the effect was more significant by LCM. Reference: Biol Pharm Bull. 2007 Dec;30(12):2312-6. https://pubmed.ncbi.nlm.nih.gov/18057718/

	Solvent	mg/mL	mM
Solubility
	DMSO	89.0	200.45
	Water	89.0	200.45

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 444.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Nameda S, Miura NN, Adachi Y, Ohno N. Lincomycin protects mice from septic shock in beta-glucan-indomethacin model. Biol Pharm Bull. 2007 Dec;30(12):2312-6. doi: 10.1248/bpb.30.2312. PMID: 18057718. 2. Kim DG, Kim HY, Kim MY, Lee MY, You KR. Lincomycin abrogates dexamethasone-enhanced melanogenesis in B16 melanoma cells. Pigment Cell Res. 1998 Jun;11(3):143-50. doi: 10.1111/j.1600-0749.1998.tb00724.x. PMID: 9730321.

In vitro protocol:

In vivo protocol:

1: Chen CE, Zhang H, Ying GG, Zhou LJ, Jones KC. Passive sampling: A cost-effective method for understanding antibiotic fate, behaviour and impact. Environ Int. 2015 Dec;85:284-91. doi: 10.1016/j.envint.2015.10.001. Epub 2015 Oct 30. PubMed PMID: 26451705.