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MedKoo Cat#: 564566 | Name: RO-7

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RO-7 is an endonuclease inhibitor which exhibits broad-spectrum anti-influenza activity in vitro.

Chemical Structure

RO-7
RO-7
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564566

Name: RO-7

CAS#: NONE

Chemical Formula: C24H20F3N3O3S

Exact Mass: 487.1177

Molecular Weight: 487.50

Elemental Analysis: C, 59.13; H, 4.14; F, 11.69; N, 8.62; O, 9.85; S, 6.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
RO7; RO 7; RO-7
IUPAC/Chemical Name
1-(5,11-Dihydro-10-thia-dibenzo[a,d]cyclohepten-5(S)-yl)-5-hydroxy-3-(2,2,2-trifluoro-1(R)-methyl-ethyl)-2,3-dihydro-1H-pyrido[2,1-f][1,2,4]triazine-4,6-dione
InChi Key
XEOTUHPFOHTFEX-VLIAUNLRSA-N
InChi Code
InChI=1S/C24H20F3N3O3S/c1-14(24(25,26)27)28-13-30(29-11-10-18(31)22(32)21(29)23(28)33)20-16-7-3-2-6-15(16)12-34-19-9-5-4-8-17(19)20/h2-11,14,20,32H,12-13H2,1H3/t14-,20+/m1/s1
SMILES Code
O=C1N([C@H](C)C(F)(F)F)CN([C@H]2C3=CC=CC=C3CSC4=CC=CC=C24)N5C1=C(O)C(C=C5)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 487.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Jones JC, Marathe BM, Vogel P, Gasser R, Najera I, Govorkova EA. The PA Endonuclease Inhibitor RO-7 Protects Mice from Lethal Challenge with Influenza A or B Viruses. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02460-16. doi: 10.1128/AAC.02460-16. Print 2017 May. PubMed PMID: 28193653; PubMed Central PMCID: PMC5404582.