MedKoo Cat#: 584508 | Name: Fmk
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Fmk is an irreversible ribosomal S6 kinase inhibitor 1/2 inhibitor.

Chemical Structure

Fmk
Fmk
CAS#821794-92-7

Theoretical Analysis

MedKoo Cat#: 584508

Name: Fmk

CAS#: 821794-92-7

Chemical Formula: C18H19FN4O2

Exact Mass: 342.1492

Molecular Weight: 342.37

Elemental Analysis: C, 63.15; H, 5.59; F, 5.55; N, 16.36; O, 9.35

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
10mg USD 650.00 2 Weeks
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Related CAS #
No Data
Synonym
Fmk; Fluoromethyl Ketone; FMK; RSK inhibitor Fmk;
IUPAC/Chemical Name
1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone
InChi Key
IKLGYJACVCXYIL-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H19FN4O2/c1-11-3-5-12(6-4-11)14-15-17(20)21-10-22-18(15)23(7-2-8-24)16(14)13(25)9-19/h3-6,10,24H,2,7-9H2,1H3,(H2,20,21,22)
SMILES Code
FCC(C1=C(C2=CC=C(C)C=C2)C3=C(N)N=CN=C3N1CCCO)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 342.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Cohen et al (2005) Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science 308 1318 PMID: 15919995 Cohen et al (2007) A clickable inhibitor reveals context-dependent autoactivation of p90 RSK. Nat.Chem.Biol. 3 156 PMID: 17259979 Kang et al (2010) p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. J.Clin.Invest. 120 1165 PMID: 20234090