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MedKoo Cat#: 584699 | Name: Romurtide sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Romurtide is a synthetic muramyl dipeptide analog; stimulates chemotactic mobility, phagocytic activity & superoxide production by neutrophils in mice; used for the prophylaxis of leukocytopenia during radiation therapy.

Chemical Structure

Romurtide sodium
Romurtide sodium
CAS#Romurtide sodium

Theoretical Analysis

MedKoo Cat#: 584699

Name: Romurtide sodium

CAS#: Romurtide sodium

Chemical Formula: C43H77N6NaO13

Exact Mass: 886.5627

Molecular Weight: 909.11

Elemental Analysis: C, 56.81; H, 8.54; N, 9.24; Na, 2.53; O, 22.88

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
78113-36-7 (free acid) Romurtide sodium
Synonym
Romurtide; MDP-lys(L18); Nopia; DJ-7041; DJ 7041; DJ7041; DJ 7041; Muroctasin; Muroctasine; Romurtide sodium
IUPAC/Chemical Name
sodium N2-((4R)-4-((2S)-2-((2R)-2-(((3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)oxy)propanamido)propanamido)-5-amino-5-oxopentanoyl)-N6-stearoyl-L-lysinate
InChi Key
WZAZCZROXBTNDF-MSCGZNDISA-M
InChi Code
InChI=1S/C43H78N6O13.Na/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23-34(52)45-26-21-20-22-32(42(58)59)48-35(53)25-24-31(39(44)55)49-40(56)28(2)46-41(57)29(3)61-38-36(47-30(4)51)43(60)62-33(27-50)37(38)54;/h28-29,31-33,36-38,43,50,54,60H,5-27H2,1-4H3,(H2,44,55)(H,45,52)(H,46,57)(H,47,51)(H,48,53)(H,49,56)(H,58,59);/q;+1/p-1/t28-,29+,31+,32-,33+,36+,37+,38+,43?;/m0./s1
SMILES Code
OC1[C@@H]([C@@H](O[C@H](C)C(N[C@@H](C)C(N[C@H](CCC(N[C@@H](CCCCNC(CCCCCCCCCCCCCCCCC)=O)C(O[Na])=O)=O)C(N)=O)=O)=O)[C@H](O)[C@H](O1)CO)NC(C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 909.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ueda H, Yamazaki M. Induction of tumor necrosis factor-alpha in solid tumor region by the orally administered synthetic muramyl dipeptide analogue, romurtide. Int Immunopharmacol. 2001 Jan;1(1):97-104. PubMed PMID: 11367521. 2: Nakajima R, Yshida Y, Akahane K, Sekiguchi M, Osada Y. Stimulatory effect of romurtide on hematopoiesis in monkeys. Arzneimittelforschung. 1991 Jan;41(1):60-5. PubMed PMID: 2049113. 3: Azuma I. Review: inducer of cytokines in vivo: overview of field and romurtide experience. Int J Immunopharmacol. 1992 Apr;14(3):487-96. Review. PubMed PMID: 1618600. 4: Yokouchi J, Hirabayashi S, Kanesaka N, Baba S, Amino M, Abe K. [Study on the most appropriate time for Romurtide administration (Nopia) in radiotherapy patients]. Gan To Kagaku Ryoho. 1997 Oct;24(13):1967-73. Japanese. PubMed PMID: 9350244. 5: Namba K, Otani T, Osada Y. Enhancement of platelet recovery in X-irradiated guinea pigs by romurtide, a synthetic muramyl dipeptide derivative. Blood. 1994 May 1;83(9):2480-8. PubMed PMID: 8167336. 6: Tatara O, Nakahama C, Niki Y. Synergistic effects of romurtide and cefmenoxime against experimental Klebsiella pneumonia in mice. Antimicrob Agents Chemother. 1992 Jan;36(1):167-71. PubMed PMID: 1590684; PubMed Central PMCID: PMC189247. 7: Nakajima R, Namba K, Ishida Y, Katsuma E, Otani T, Osada Y. Synergistic effect of romurtide with ampicillin against pneumococcal pneumonia in mice. Chemotherapy. 1992;38(4):238-50. PubMed PMID: 1473363. 8: Yano K, Matsuoka H, Seo Y, Kounoe S, Saito T, Tomoda H. Restorative effect of romurtide for thrombocytopenia associated with intensive anticancer drug treatment and/or irradiation in patients with gastrointestinal cancer. Anticancer Res. 1995 Nov-Dec;15(6B):2883-7. PubMed PMID: 8669883. 9: Namba K, Nitanai H, Otani T, Azuma I. Romurtide, a synthetic muramyl dipeptide derivative, accelerates peripheral platelet recovery in nonhuman primate chemotherapy model. Vaccine. 1996 Oct;14(14):1322-6. PubMed PMID: 9004440. 10: Namba K, Yamamura E, Nitanai H, Otani T, Azuma I. Romurtide, a synthetic muramyl dipeptide derivative, promotes megakaryocytopoiesis through stimulation of cytokine production in nonhuman primates with myelosuppression. Vaccine. 1997 Mar;15(4):405-13. PubMed PMID: 9141212. 11: Suzuki K, Torii K, Hida S, Hayashi H, Hiyama Y, Oomoto Y, Takii T, Chiba T, Onozaki K. Differences in interleukin 1 (IL-1), IL-6, tumor necrosis factor and IL-1 receptor antagonist production by human monocytes stimulated with muramyl dipeptide (MDP) and its stearoyl derivative, romurtide. Immunopharmacology. 1994 Jul-Aug;28(1):31-8. PubMed PMID: 7928300. 12: Namba K, Nakajima R, Otani T, Azuma I. Oral application of romurtide, a synthetic muramyl dipeptide derivative, stimulates nonspecific resistance to microbial infections and hematopoiesis in mice. Vaccine. 1996 Aug;14(12):1149-53. PubMed PMID: 8911012. 13: Armstrong NA, Bolton EJ, Morris DL. Study on the reduction of chemotherapy induced neutropenia in mice using glucosaminylmuramyl dipeptide. Arzneimittelforschung. 1999 Aug;49(8):716-20. PubMed PMID: 10483520. 14: Hasegawa J, Satoh A, Yagi K, Chida K. [Augmentation of immune defense mechanisms of the lung by romurtide]. Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Jun;33(6):605-11. Japanese. PubMed PMID: 7666614. 15: Azuma I. Development of the cytokine inducer romurtide: experimental studies and clinical application. Trends Pharmacol Sci. 1992 Dec;13(12):425-8. Review. PubMed PMID: 1293866. 16: Shimoda K, Okamura S, Harada N, Omori F, Niho Y. Production of interleukin-6 from macrophages by MDP-Lys (L 18), romurtide. Res Commun Chem Pathol Pharmacol. 1990 Dec;70(3):289-96. PubMed PMID: 2093210. 17: Azuma I, Otani T. Potentiation of host defense mechanism against infection by a cytokine inducer, an acyl-MDP derivative, MDP-Lys(L18) (romurtide) in mice and humans. Med Res Rev. 1994 Jul;14(4):401-14. Review. PubMed PMID: 8084203. 18: Maekawa Y, Anzai T, Yoshikawa T, Sugano Y, Mahara K, Kohno T, Takahashi T, Ogawa S. Effect of granulocyte-macrophage colony-stimulating factor inducer on left ventricular remodeling after acute myocardial infarction. J Am Coll Cardiol. 2004 Oct 6;44(7):1510-20. PubMed PMID: 15464336. 19: Niki Y, Tatara O. Therapeutic and prophylactic effects of romurtide against experimental animal infections. Adv Exp Med Biol. 1992;319:185-91. PubMed PMID: 1414593. 20: Yanagawa H, Haku T, Takeuchi E, Suzuki Y, Nokihara H, Sone S. Intrapleural therapy with MDP-Lys (L18), a synthetic derivative of muramyl dipeptide, against malignant pleurisy associated with lung cancer. Lung Cancer. 2000 Feb;27(2):67-73. PubMed PMID: 10688489.

View History

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