Neothramycin A | CAS#59593-16-7 | antibiotic

MedKoo Cat#: 584688 | Name: Neothramycin A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Neothramycin A is a pyrrol[1,4]benzodiazepine antibiotic.

Chemical Structure

Neothramycin A

CAS#59593-16-7

Theoretical Analysis

MedKoo Cat#: 584688

Name: Neothramycin A

CAS#: 59593-16-7

Chemical Formula: C13H14N2O4

Exact Mass: 262.0954

Molecular Weight: 262.27

Elemental Analysis: C, 59.54; H, 5.38; N, 10.68; O, 24.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Neothramycin A; Antibiotic MC-916-A; MC-916-A

IUPAC/Chemical Name

5H-Pyrrolo(2,1-c)(1,4)benzodiazepin-5-one, 1,2,3,11a-tetrahydro-3,8-dihydroxy-7-methoxy-, (3S-trans)-

InChi Key

FXMOIYLVKOALHC-MADCSZMMSA-N

InChi Code

InChI=1S/C13H14N2O4/c1-19-11-4-8-9(5-10(11)16)14-6-7-2-3-12(17)15(7)13(8)18/h4-7,12,16-17H,2-3H2,1H3/t7-,12-/m0/s1

SMILES Code

O=C1N2[C@](CC[C@@H]2O)([H])C=NC3=CC(O)=C(OC)C=C13

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 262.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rao SN, Remers WA. All atom molecular mechanics simulations on covalent complexes of anthramycin and neothramycin with deoxydecanucleotides. J Med Chem. 1990 Jun;33(6):1701-7. PubMed PMID: 2342065. 2: Remers WA, Mabilia M, Hopfinger AJ. Conformations of complexes between pyrrolo[1,4]benzodiazepines and DNA segments. J Med Chem. 1986 Dec;29(12):2492-503. PubMed PMID: 3783609. 3: Petrusek RL, Anderson GL, Garner TF, Fannin QL, Kaplan DJ, Zimmer SG, Hurley LH. Pyrrol[1,4]benzodiazepine antibiotics. Proposed structures and characteristics of the in vitro deoxyribonucleic acid adducts of anthramycin, tomaymycin, sibiromycin, and neothramycins A and B. Biochemistry. 1981 Mar 3;20(5):1111-9. PubMed PMID: 6261786. 4: Morris SJ, Thurston DE, Nevell TG. Evaluation of the electrophilicity of DNA-binding pyrrolo[2,1-c][1,4]benzodiazepines by HPLC. J Antibiot (Tokyo). 1990 Oct;43(10):1286-92. PubMed PMID: 2258327.