HyP-1 | Hypoxia Probe

MedKoo Cat#: 564512 | Name: HyP-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HyP-1 is a probe for photoacoustic imaging of hypoxia.

Chemical Structure

HyP-1

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564512

Name: HyP-1

CAS#: NONE

Chemical Formula: C37H33BF2N4O2

Exact Mass: 614.2665

Molecular Weight: 614.50

Elemental Analysis: C, 72.32; H, 5.41; B, 1.76; F, 6.18; N, 9.12; O, 5.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Hypoxia Probe 1; HyP1; HyP 1; HyP-1

IUPAC/Chemical Name

4-(5,5-Difluoro-7-(4-methoxyphenyl)-1,9-diphenyl-5H-5l4,6l4-dipyrrolo[1,2-c:2',1'-f][1,3,5,2]triazaborinin-3-yl)-N,N-diethylaniline oxide

InChi Key

PRFNSYCZKOLTBL-UHFFFAOYSA-N

InChi Code

InChI=1S/C37H33BF2N4O2/c1-4-44(45,5-2)30-20-16-28(17-21-30)34-24-32(26-12-8-6-9-13-26)36-41-37-33(27-14-10-7-11-15-27)25-35(43(37)38(39,40)42(34)36)29-18-22-31(46-3)23-19-29/h6-25H,4-5H2,1-3H3

SMILES Code

CC[N+](CC)([O-])C1=CC=C(C2=CC(C3=CC=CC=C3)=C4N2B(F)(F)[N]5=C(C6=CC=C(OC)C=C6)C=C(C7=CC=CC=C7)C5=N4)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 614.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Michalska K, Fernandes H, Sikorski M, Jaskolski M. Crystal structure of Hyp-1, a St. John's wort protein implicated in the biosynthesis of hypericin. J Struct Biol. 2010 Feb;169(2):161-71. doi: 10.1016/j.jsb.2009.10.008. Epub 2009 Oct 21. PubMed PMID: 19853038. 2: Karppinen K, Taulavuori E, Hohtola A. Optimization of protein extraction from Hypericum perforatum tissues and immunoblotting detection of Hyp-1 at different stages of leaf development. Mol Biotechnol. 2010 Nov;46(3):219-26. doi: 10.1007/s12033-010-9299-9. PubMed PMID: 20563670. 3: Karppinen K, Derzsó E, Jaakola L, Hohtola A. Molecular Cloning and Expression Analysis of hyp-1 Type PR-10 Family Genes in Hypericum perforatum. Front Plant Sci. 2016 Apr 21;7:526. doi: 10.3389/fpls.2016.00526. eCollection 2016. PubMed PMID: 27148343; PubMed Central PMCID: PMC4838893. 4: Sliwiak J, Dauter Z, Jaskolski M. Crystal Structure of Hyp-1, a Hypericum perforatum PR-10 Protein, in Complex with Melatonin. Front Plant Sci. 2016 May 18;7:668. doi: 10.3389/fpls.2016.00668. eCollection 2016. PubMed PMID: 27242869; PubMed Central PMCID: PMC4870859. 5: Knox HJ, Hedhli J, Kim TW, Khalili K, Dobrucki LW, Chan J. A bioreducible N-oxide-based probe for photoacoustic imaging of hypoxia. Nat Commun. 2017 Nov 27;8(1):1794. doi: 10.1038/s41467-017-01951-0. PubMed PMID: 29176550; PubMed Central PMCID: PMC5702603.