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MedKoo Cat#: 584681 | Name: Mafoprazine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mafoprazine is an antipsychotic drug with antiapomorphine and anti-methamphetamine actions.

Chemical Structure

Mafoprazine
Mafoprazine
CAS#80428-29-1 (free base)

Theoretical Analysis

MedKoo Cat#: 584681

Name: Mafoprazine

CAS#: 80428-29-1 (free base)

Chemical Formula: C22H28FN3O3

Exact Mass: 401.2115

Molecular Weight: 401.48

Elemental Analysis: C, 65.82; H, 7.03; F, 4.73; N, 10.47; O, 11.95

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
80428-31-5 (mesylate) 80428-29-1 (free base)
Synonym
Mafoprazine
IUPAC/Chemical Name
4'-(3-(4-(o-Fluorophenyl)-1-piperazinyl)propoxy)-m-acetanisidide
InChi Key
PHOCQBYGUQPMIB-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H28FN3O3/c1-17(27)24-18-8-9-21(22(16-18)28-2)29-15-5-10-25-11-13-26(14-12-25)20-7-4-3-6-19(20)23/h3-4,6-9,16H,5,10-15H2,1-2H3,(H,24,27)
SMILES Code
CC(NC1=CC=C(OCCCN2CCN(C3=CC=CC=C3F)CC2)C(OC)=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 401.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yamamura M, Nakagawa H, Maeda K, Kinoshita K, Ishida R. Effects of mafoprazine, a phenylpiperazine derivative, on the central dopaminergic system. Jpn J Pharmacol. 1989 Jul;50(3):295-305. PubMed PMID: 2569544. 2: Yamamura M, Nakagawa H, Kinoshita K, Ochiai T, Ishida R. A behavioral pharmacological study of mafoprazine, a new phenylpiperazine derivative. Jpn J Pharmacol. 1988 Oct;48(2):203-12. PubMed PMID: 3210446. 3: Fukuchi I, Kawashima K, Matsuoka Y, Ishida R. Neurochemical study of mafoprazine, a new phenylpiperazine derivative. Jpn J Pharmacol. 1988 May;47(1):51-61. PubMed PMID: 3411821. 4: Rao TS, Mick SJ, Cler JA, Emmett MR, Dilworth VM, Contreras PC, Gray NM, Wood PL, Iyengar S. Effects of sigma ligands on mouse cerebellar cyclic guanosine monophosphate (cGMP) levels in vivo: further evidence for a functional modulation of N-methyl-D-aspartate (NMDA) receptor complex-mediated events by sigma ligands. Brain Res. 1991 Oct 4;561(1):43-50. PubMed PMID: 1686745.