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MedKoo Cat#: 573167 | Name: Antrafenine free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Antrafenine, also known as Stakane, is a phenylpiperazine derivative drug. It acts as an analgesic and anti-inflammatory with similar efficacy to naproxen.

Chemical Structure

Antrafenine free base
Antrafenine free base
CAS#55300-29-3 (free base)

Theoretical Analysis

MedKoo Cat#: 573167

Name: Antrafenine free base

CAS#: 55300-29-3 (free base)

Chemical Formula: C30H26F6N4O2

Exact Mass: 588.1960

Molecular Weight: 588.55

Elemental Analysis: C, 61.22; H, 4.45; F, 19.37; N, 9.52; O, 5.44

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
55300-29-3 (free base) 55300-30-6 (HCl)
Synonym
Antrafenine, SL 73-033, SL-73-033; SL73-033; SL 73033, SL-73033; SL73033; Stakan, Stakane; Antrafenine free base,
IUPAC/Chemical Name
2-(4-(alpha,alpha,alpha-Trifluoro-m-tolyl)-1-piperazinyl)ethyl N-(7-(trifluoromethyl)-4-quinolyl)anthranilate
InChi Key
NWGGKKGAFZIVBJ-UHFFFAOYSA-N
InChi Code
1S/C30H26F6N4O2/c31-29(32,33)20-4-3-5-22(18-20)40-14-12-39(13-15-40)16-17-42-28(41)24-6-1-2-7-25(24)38-26-10-11-37-27-19-21(30(34,35)36)8-9-23(26)27/h1-11,18-19H,12-17H2,(H,37,38)
SMILES Code
C(F)(F)(F)c1cc2nccc(c2cc1)Nc1c(C(OCCN2CCN(CC2)c2cc(ccc2)C(F)(F)F)=O)cccc1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 588.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wang Y, Law WK, Hu JS, Lin HQ, Ip TM, Wan DC. Discovery of FDA-approved drugs as inhibitors of fatty acid binding protein 4 using molecular docking screening. J Chem Inf Model. 2014 Nov 24;54(11):3046-50. doi: 10.1021/ci500503b. Epub 2014 Nov 4. PubMed PMID: 25360897. 2: Dunn CJ, Prouteau M, Delahaye M, Purcell T, Branceni D. Antrafenine: anti-inflammatory activity with respect to oedema and leucocyte infiltration in the rat. Agents Actions. 1984 Feb;14(2):296-9. PubMed PMID: 6608864. 3: Berry H, Coquelin JP, Gordon A, Seymour D. Antrafenine, naproxen and placebo in osteoarthritis: a comparative study. Br J Rheumatol. 1983 May;22(2):89-94. PubMed PMID: 6342700. 4: Leatham PA, Bird HA, Wright V, Seymour D, Gordon A. A double blind study of antrafenine, naproxen and placebo in osteoarthrosis. Eur J Rheumatol Inflamm. 1983;6(2):209-11. PubMed PMID: 6673985. 5: Hassan SM, Olivesi A, Fish A, Turner P. A comparison of antrafenine and aspirin on platelet aggregation and frusemide-induced diuresis. Postgrad Med J. 1982 Jan;58(675):17-9. PubMed PMID: 7088753; PubMed Central PMCID: PMC2426228.