GSK2646264 is a potent, selective Spleen Tyrosine Kinase (Syk) inhibitor with pIC50 of 7.1, >300-fold selectivity over Autota B. GSK2646264 is potentially useful for the topical treatment of inflammatory skin disease. GSK2646264 was selected for progression and is currently in Phase I clinical trials.
MedKoo Cat#: 555362
Name: GSK2646264 free base
CAS#: 1398695-47-0 (free base)
Chemical Formula: C24H26N2O2
Exact Mass: 374.1994
Molecular Weight: 374.48
Elemental Analysis: C, 76.98; H, 7.00; N, 7.48; O, 8.54
The following data is based on the product molecular weight 374.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
