S55746 also known as BCL201, is a potent and selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. BCL201 binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells. S55746 potently impairs hematological tumor growth. S55746 occupies the hydrophobic groove of BCL-2. S55746 induces hallmarks of apoptosis including externalization of phosphatidylserine, caspase-3 activation and PARP cleavage. Ex vivo, S55746 induces apoptosis in the low nanomolar range in primary Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma patient samples.
MedKoo Cat#: 407949
Name: S-55746
CAS#: 1448584-12-0
Chemical Formula: C43H42N4O6
Exact Mass: 710.3104
Molecular Weight: 710.83
Elemental Analysis: C, 72.66; H, 5.96; N, 7.88; O, 13.50
The following data is based on the product molecular weight 710.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
