Synonym
Ximoprofen; Ximoprofeno; Ximoprofenum.
IUPAC/Chemical Name
Benzeneacetic acid, 4-(3-(hydroxyimino)cyclohexyl)-alpha-methyl-
InChi Key
IQPPOXSMSDPZKU-JQIJEIRASA-N
InChi Code
InChI=1S/C15H19NO3/c1-10(15(17)18)11-5-7-12(8-6-11)13-3-2-4-14(9-13)16-19/h5-8,10,13,19H,2-4,9H2,1H3,(H,17,18)/b16-14+
SMILES Code
O=C(O)C(C)C1=CC=C(C2C/C(CCC2)=N/O)C=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
261.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Dougados M, Nguyen M, Caporal R, Legeais J, Bouxin-Sauzet A, Pellegri-Guegnault B, Gomeni C. Ximoprofen in ankylosing spondylitis. A double blind placebo controlled dose ranging study. Scand J Rheumatol. 1994;23(5):243-8. PubMed PMID: 7973477.
2: Taylor IW, Chasseaud LF, Taylor T, James I, Dorf G, Darragh A. Pharmacokinetics of the anti-inflammatory drug ximoprofen in healthy young and elderly subjects: comparison with elderly rheumatic patients. Br J Clin Pharmacol. 1991 Aug;32(2):242-5. PubMed PMID: 1931475; PubMed Central PMCID: PMC1368451.
3: Taylor IW, Taylor T, James I, Doyle G, Dorf G, Darragh A, Chasseaud LF. Pharmacokinetics of the anti-inflammatory drug ximoprofen in healthy subjects and in disease states. Eur J Clin Pharmacol. 1991;40(1):101-6. PubMed PMID: 2060536.
4: Morris GR, Walmsley LM, Brodie RR, Chasseaud LF. Determination of ximoprofen and its metabolites in human urine by high-performance liquid chromatography with ultraviolet absorbance detection. J Chromatogr. 1990 Sep 14;530(2):377-85. PubMed PMID: 2079512.
5: Mayo BC, Chasseaud LF, Hawkins DR, Taylor IW, Legeai J. The metabolic fate of 14C-ximoprofen in rats, baboons and humans. Xenobiotica. 1990 Mar;20(3):233-46. PubMed PMID: 2336835.
6: Pairet M, Ruckebusch Y. On the relevance of non-steroidal anti-inflammatory drugs in the prevention of paralytic ileus in rodents. J Pharm Pharmacol. 1989 Nov;41(11):757-61. PubMed PMID: 2576043.
7: Taylor IW, Chasseaud LF. Determination of ximoprofen in human plasma by gas chromatography. J Chromatogr. 1989 Oct 27;495:275-80. PubMed PMID: 2613813.
8: Dougados M, Caporal R, Doury P, Thiesce A, Pattin S, Laffez B, Amor B. A double blind crossover placebo controlled trial of ximoprofen in as. J Rheumatol. 1989 Aug;16(8):1167-9. PubMed PMID: 2685299.
