LY195448 is an experimental drug that blocks cells at metaphase. LY195448 is cytotoxic to mammalian cells because it inhibits microtubule assembly, most likely through a direct interaction with tubulin. LY195448 has demonstrated cytotoxic activity against cell cultures in vitro but that exhibited a hypotensive side effect during phase I trials.
MedKoo Cat#: 529165
Name: LY195448
CAS#: 111974-80-2
Chemical Formula: C20H26N2O2
Exact Mass: 326.1994
Molecular Weight: 326.44
Elemental Analysis: C, 73.59; H, 8.03; N, 8.58; O, 9.80
The following data is based on the product molecular weight 326.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
