MedKoo Cat#: 529150 | Name: Itazigrel

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Itazigrel is a platelet aggregation inhibitor.

Chemical Structure

Itazigrel
Itazigrel
CAS#70529-35-0

Theoretical Analysis

MedKoo Cat#: 529150

Name: Itazigrel

CAS#: 70529-35-0

Chemical Formula: C18H14F3NO2S

Exact Mass: 365.0697

Molecular Weight: 365.37

Elemental Analysis: C, 59.17; H, 3.86; F, 15.60; N, 3.83; O, 8.76; S, 8.77

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Itazigrel
IUPAC/Chemical Name
Thiazole, 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)-
InChi Key
CIPBQTCSXVEDSG-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H14F3NO2S/c1-23-13-7-3-11(4-8-13)15-16(25-17(22-15)18(19,20)21)12-5-9-14(24-2)10-6-12/h3-10H,1-2H3
SMILES Code
FC(C1=NC(C2=CC=C(OC)C=C2)=C(C3=CC=C(OC)C=C3)S1)(F)F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 365.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liga F, Ingoglia S, Inguglia C, Lo Coco A, Lo Cricchio MG, Musso P, Cheah C, Rose L, Gutow MR. Associations Among Psychologically Controlling Parenting, Autonomy, Relatedness, and Problem Behaviors During Emerging Adulthood. J Psychol. 2017 May 19;151(4):393-415. doi: 10.1080/00223980.2017.1305323. Epub 2017 Apr 7. PubMed PMID: 28388337. 2: Hsyu PH, Koets MD, Luderer JR. Pharmacokinetics and cyclooxygenase inhibition of itazigrel in normal volunteers after single oral doses. J Pharm Sci. 1994 Dec;83(12):1747-50. PubMed PMID: 7891305. 3: Yamamoto K, Shah AC, Nishihata T. Enhanced rectal absorption of itazigrel formulated with polysorbate 80 micelle vehicle in rat: role of co-administered esterase. J Pharm Pharmacol. 1994 Jul;46(7):608-11. PubMed PMID: 7996393. 4: Tanaka A, Sakai H, Motoyama Y, Ishikawa T, Takasugi H. Antiplatelet agents based on cyclooxygenase inhibition without ulcerogenesis. Evaluation and synthesis of 4,5-bis(4-methoxyphenyl)-2-substituted-thiazoles. J Med Chem. 1994 Apr 15;37(8):1189-99. PubMed PMID: 8164261. 5: Nishihata T, Yamamoto K, Ishizaka M. Use of enzymatic activity for design of orally administered enteric dosing forms. J Pharm Pharmacol. 1993 Nov;45(11):947-50. PubMed PMID: 7908034. 6: Dunwiddie TV, Taylor M, Cass WA, Fitzpatrick FA, Zahniser NR. Arachidonic acid metabolites do not mediate modulation of neurotransmitter release by adenosine in rat hippocampus or striatum. Brain Res. 1990 Sep 10;527(1):76-80. PubMed PMID: 1980842. 7: Bombardt PA, Brewer JE, Thomas RC Jr, Koets MD. Simple, rapid and sensitive high-performance liquid chromatographic procedure for the quantitation of itazigrel in human plasma or serum. J Chromatogr. 1990 Apr 27;527(1):233-7. PubMed PMID: 2365787. 8: Bombardt PA, Bothwell BE, Closson SK, Adams WJ. Quantitative determination of itazigrel in rodent diet by reversed-phase HPLC and evaluation of its stability at 20 degrees C. Biomed Chromatogr. 1989 Jul;3(4):180-2. PubMed PMID: 2590729. 9: Demke DM, Luderer JR, Wakefield LK, Euler AR, Brouwer RD, Metzler CM. The effect of itazigrel and aspirin on the mucosa of the esophagus, stomach, and duodenum of normal subjects. J Clin Pharmacol. 1987 Nov;27(11):916-20. PubMed PMID: 3429698. 10: Schaub RG, Keith JC Jr, Simmons CA, Rawlings CA. Smooth muscle proliferation in chronically injured canine pulmonary arteries is reduced by a potent platelet aggregation inhibitor U-53,059. Thromb Haemost. 1985 Jun 24;53(3):351-5. PubMed PMID: 4049309. 11: Schaub RG, Simmons CA. Medial smooth muscle cell proliferation in the balloon injured rabbit aorta: effect of a thiazole compound with platelet inhibitory activity. Thromb Haemost. 1984 Feb 28;51(1):75-8. PubMed PMID: 6719391. 12: Nishizawa EE, Mendoza AR, Honohan T, Annis KA. A thiazole compound with potential antithrombotic activity. Thromb Haemost. 1982 Apr 30;47(2):173-6. PubMed PMID: 7101238.