MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 584656 | Name: Clorgyline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clorgyline is an antidepressive agent and monoamine oxidase inhibitor related to PARGYLINE.

Chemical Structure

Clorgyline
CAS#17780-72-2 (free base)

Theoretical Analysis

MedKoo Cat#: 584656

Name: Clorgyline

CAS#: 17780-72-2 (free base)

Chemical Formula: C13H15Cl2NO

Exact Mass: 271.0531

Molecular Weight: 272.17

Elemental Analysis: C, 57.37; H, 5.56; Cl, 26.05; N, 5.15; O, 5.88

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
17780-72-2 (free base) 17780-75-5 (HCl)
Synonym
Clorgyline; Clorgiline; M & B 9302; M and B 9302; M&B 9302; Clorgilinum; Chlorgyline;
IUPAC/Chemical Name
2-Propyn-1-amine, N-(3-(2,4-dichlorophenoxy)propyl)-N-methyl- (9CI)
InChi Key
BTFHLQRNAMSNLC-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3
SMILES Code
C#CCN(CCCOC1=CC=C(Cl)C=C1Cl)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 272.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shih JC. Monoamine oxidase isoenzymes: genes, functions and targets for behavior and cancer therapy. J Neural Transm (Vienna). 2018 Nov;125(11):1553-1566. doi: 10.1007/s00702-018-1927-8. Epub 2018 Sep 27. Review. PubMed PMID: 30259128. 2: Altintop MD, Sever B, Osmaniye D, Sağlık BN, Özdemir A. Design, synthesis, in vitro and in silico evaluation of new pyrrole derivatives as monoamine oxidase inhibitors. Arch Pharm (Weinheim). 2018 Jul;351(7):e1800082. doi: 10.1002/ardp.201800082. Epub 2018 May 22. PubMed PMID: 29963739. 3: Pandey P, Chaurasiya ND, Tekwani BL, Doerksen RJ. Interactions of endocannabinoid virodhamine and related analogs with human monoamine oxidase-A and -B. Biochem Pharmacol. 2018 Sep;155:82-91. doi: 10.1016/j.bcp.2018.06.024. Epub 2018 Jun 26. PubMed PMID: 29958841. 4: Wang Z, Olenyuk BZ, Shih JC, Wang J. Quantification and pharmacokinetic study of tumor-targeting agent MHI148-clorgyline amide in mouse plasma using liquid chromatography-electrospray ionization tandem mass spectrometry. J Pharm Anal. 2018 Jun;8(3):153-159. doi: 10.1016/j.jpha.2017.10.001. Epub 2017 Oct 20. PubMed PMID: 29922483; PubMed Central PMCID: PMC6004616. 5: Liao CP, Lin TP, Li PC, Geary LA, Chen K, Vaikari VP, Wu JB, Lin CH, Gross ME, Shih JC. Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate. Oncogene. 2018 Sep;37(38):5175-5190. doi: 10.1038/s41388-018-0325-x. Epub 2018 May 29. PubMed PMID: 29844571. 6: Baek SC, Lee HW, Ryu HW, Kang MG, Park D, Kim SH, Cho ML, Oh SR, Kim H. Selective inhibition of monoamine oxidase A by hispidol. Bioorg Med Chem Lett. 2018 Feb 15;28(4):584-588. doi: 10.1016/j.bmcl.2018.01.049. Epub 2018 Jan 31. PubMed PMID: 29395970. 7: Kliman HJ, Quaratella SB, Setaro AC, Siegman EC, Subha ZT, Tal R, Milano KM, Steck TL. Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology. 2018 Apr 1;159(4):1609-1629. doi: 10.1210/en.2017-03025. PubMed PMID: 29381782. 8: Bellusci L, Laurino A, Sabatini M, Sestito S, Lenzi P, Raimondi L, Rapposelli S, Biagioni F, Fornai F, Salvetti A, Rossi L, Zucchi R, Chiellini G. New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection. Front Pharmacol. 2017 Dec 12;8:905. doi: 10.3389/fphar.2017.00905. eCollection 2017. PubMed PMID: 29311919; PubMed Central PMCID: PMC5732922. 9: Herraiz T, Flores A, Fernández L. Analysis of monoamine oxidase (MAO) enzymatic activity by high-performance liquid chromatography-diode array detection combined with an assay of oxidation with a peroxidase and its application to MAO inhibitors from foods and plants. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 15;1073:136-144. doi: 10.1016/j.jchromb.2017.12.004. Epub 2017 Dec 6. PubMed PMID: 29268246. 10: Uțu D, Pantea S, Duicu OM, Muntean DM, Sturza A. Contribution of monoamine oxidases to vascular oxidative stress in patients with end-stage renal disease requiring hemodialysis. Can J Physiol Pharmacol. 2017 Nov;95(11):1383-1388. doi: 10.1139/cjpp-2017-0067. Epub 2017 Jul 28. PubMed PMID: 28753408. 11: Fonseca A, Reis J, Silva T, Matos MJ, Bagetta D, Ortuso F, Alcaro S, Uriarte E, Borges F. Coumarin versus Chromone Monoamine Oxidase B Inhibitors: Quo Vadis? J Med Chem. 2017 Aug 24;60(16):7206-7212. doi: 10.1021/acs.jmedchem.7b00918. Epub 2017 Aug 10. PubMed PMID: 28753307. 12: Esquivel BD, White TC. Accumulation of Azole Drugs in the Fungal Plant Pathogen Magnaporthe oryzae Is the Result of Facilitated Diffusion Influx. Front Microbiol. 2017 Jul 13;8:1320. doi: 10.3389/fmicb.2017.01320. eCollection 2017. PubMed PMID: 28751884; PubMed Central PMCID: PMC5508014. 13: Li PC, Siddiqi IN, Mottok A, Loo EY, Wu CH, Cozen W, Steidl C, Shih JC. Monoamine oxidase A is highly expressed in classical Hodgkin lymphoma. J Pathol. 2017 Oct;243(2):220-229. doi: 10.1002/path.4944. Epub 2017 Sep 5. PubMed PMID: 28722111; PubMed Central PMCID: PMC5605421. 14: Laurino A, Lucenteforte E, De Siena G, Raimondi L. The impact of scopolamine pretreatment on 3-iodothyronamine (T1AM) effects on memory and pain in mice. Horm Behav. 2017 Aug;94:93-96. doi: 10.1016/j.yhbeh.2017.07.003. Epub 2017 Jul 19. PubMed PMID: 28711308. 15: Nagayoshi Y, Miyazaki T, Shimamura S, Nakayama H, Minematsu A, Yamauchi S, Takazono T, Nakamura S, Yanagihara K, Kohno S, Mukae H, Izumikawa K. Unexpected effects of azole transporter inhibitors on antifungal susceptibility in Candida glabrata and other pathogenic Candida species. PLoS One. 2017 Jul 11;12(7):e0180990. doi: 10.1371/journal.pone.0180990. eCollection 2017. PubMed PMID: 28700656; PubMed Central PMCID: PMC5507446. 16: Lam CS, Li JJ, Tipoe GL, Youdim MBH, Fung ML. Monoamine oxidase A upregulated by chronic intermittent hypoxia activates indoleamine 2,3-dioxygenase and neurodegeneration. PLoS One. 2017 Jun 9;12(6):e0177940. doi: 10.1371/journal.pone.0177940. eCollection 2017. PubMed PMID: 28599322; PubMed Central PMCID: PMC5466431. 17: Ayala-Lopez N, Thompson JM, Watts SW. Perivascular Adipose Tissue's Impact on Norepinephrine-Induced Contraction of Mesenteric Resistance Arteries. Front Physiol. 2017 Feb 8;8:37. doi: 10.3389/fphys.2017.00037. eCollection 2017. PubMed PMID: 28228728; PubMed Central PMCID: PMC5296360. 18: De Deurwaerdère P, Binda C, Corne R, Leone C, Valeri A, Valoti M, Ramsay RR, Fall Y, Marco-Contelles J. Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine. ACS Chem Neurosci. 2017 May 17;8(5):1026-1035. doi: 10.1021/acschemneuro.6b00377. Epub 2016 Dec 30. PubMed PMID: 27977122. 19: Abbas N, Zaib S, Bakht SM, Ibrar A, Khan I, Batool S, Saeed A, Iqbal J. Symmetrical aryl linked bis-iminothiazolidinones as new chemical entities for the inhibition of monoamine oxidases: Synthesis, in vitro biological evaluation and molecular modelling analysis. Bioorg Chem. 2017 Feb;70:17-26. doi: 10.1016/j.bioorg.2016.11.004. Epub 2016 Nov 9. PubMed PMID: 27863747. 20: Popova D, Forsblad A, Hashemian S, Jacobsson SO. Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells. PLoS One. 2016 Nov 18;11(11):e0166750. doi: 10.1371/journal.pone.0166750. eCollection 2016. PubMed PMID: 27861613; PubMed Central PMCID: PMC5115802.