EG01377 TFA | CAS# 2227996-00-9 | NRP1 Antagonist

MedKoo Cat#: 564391 | Name: EG01377 TFA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

EG01377 TFA salt is a selective neuropilin-1 (NRP1) antagonist, which shows immune modulation through reduction of transforming growth factor beta (TGFβ) production in regulatory T-cells, as well as immune modulation through anti-angiogenic, anti-migratory, and anti-tumour effects.

Chemical Structure

EG01377 TFA

CAS#Unknown (TFA)

Theoretical Analysis

MedKoo Cat#: 564391

Name: EG01377 TFA

CAS#: Unknown (TFA)

Chemical Formula: C28H31F3N6O8S2

Exact Mass: 700.1597

Molecular Weight: 700.71

Elemental Analysis: C, 48.00; H, 4.46; F, 8.13; N, 11.99; O, 18.27; S, 9.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

2227996-00-9 (free base)

Synonym

EG-01377 TFA; EG 01377 TFA; EG01377 TFA; EG-01377; EG01377;

IUPAC/Chemical Name

(3-((5-(4-(aminomethyl)phenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-L-arginine compound with 2,2,2-trifluoroacetic acid (1:1)

InChi Key

ULVKWGGHMNAQEG-BDQAORGHSA-N

InChi Code

InChI=1S/C26H30N6O6S2.C2HF3O2/c27-14-15-3-5-16(6-4-15)18-12-17-7-10-38-22(17)21(13-18)40(36,37)32-19-8-11-39-23(19)24(33)31-20(25(34)35)2-1-9-30-26(28)29;3-2(4,5)1(6)7/h3-6,8,11-13,20,32H,1-2,7,9-10,14,27H2,(H,31,33)(H,34,35)(H4,28,29,30);(H,6,7)/t20-;/m0./s1

SMILES Code

NC(NCCC[C@H](NC(C1=C(NS(=O)(C2=C(OCC3)C3=CC(C4=CC=C(CN)C=C4)=C2)=O)C=CS1)=O)C(O)=O)=N.OC(C(F)(F)F)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 700.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.