Synonym
LY-79771; LY 79771; LY79771; LY-79771 free base
IUPAC/Chemical Name
4-((S)-3-(((R)-2-hydroxy-2-phenylethyl)amino)butyl)phenol
InChi Key
APNAMANVPJZNEW-KSSFIOAISA-N
InChi Code
InChI=1S/C18H23NO2/c1-14(7-8-15-9-11-17(20)12-10-15)19-13-18(21)16-5-3-2-4-6-16/h2-6,9-12,14,18-21H,7-8,13H2,1H3/t14-,18-/m0/s1
SMILES Code
O[C@@H](CN[C@@H](C)CCC1=CC=C(O)C=C1)C2=CC=CC=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
285.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Blin N, Nahmias C, Drumare MF, Strosberg AD. Mediation of most atypical effects by species homologues of the beta 3-adrenoceptor. Br J Pharmacol. 1994 Jul;112(3):911-9. PubMed PMID: 7921620; PubMed Central PMCID: PMC1910199.
2: Blin N, Camoin L, Maigret B, Strosberg AD. Structural and conformational features determining selective signal transduction in the beta 3-adrenergic receptor. Mol Pharmacol. 1993 Dec;44(6):1094-104. PubMed PMID: 7903415.
3: Parente JA Jr, Berdanier CD. Drugs that suppress hepatic fat synthesis in starved-refed BHE/cdb rats also have an effect on muscle protein synthesis. Proc Soc Exp Biol Med. 1993 Nov;204(2):172-9. PubMed PMID: 8415772.
4: Cooper DA, Berdanier CD. The drug LY79771 affects fat regain by starved and refed BHE rats. J Nutr. 1991 Nov;121(11):1827-33. PubMed PMID: 1941191.
5: Ashwell M, Stirling D, Freeman S, Holloway BR. Immunological, histological and biochemical assessment of brown adipose tissue activity in neonatal, control and beta-stimulant-treated adult dogs. Int J Obes. 1987;11(4):357-65. PubMed PMID: 2889691.
6: Holloway BR, Stribling D, Freeman S, Jamieson L. The thermogenic role of adipose tissue in the dog. Int J Obes. 1985;9(6):423-32. PubMed PMID: 3007382.
7: Yen TT. The antiobesity and metabolic activities of LY79771 in obese and normal mice. Int J Obes. 1984;8(1):69-78. PubMed PMID: 6368435.
8: Yen TT, McKee MM, Stamm NB, Bemis KG. Stimulation of cyclic AMP and lipolysis in adipose tissue of normal and obese Avy/a mice by LY79771, a phenethanolamine, and stereoisomers. Life Sci. 1983 Mar 28;32(13):1515-22. PubMed PMID: 6300583.
9: Shaw WN, Schmiegel KK, Yen TT, Toomey RE, Meyers DB, Mills J. LY79771: a novel compound for weight control. Life Sci. 1981 Nov 16;29(20):2091-101. PubMed PMID: 7053089.
