T-2 triol | 34114-98-2 | toxic fungus

MedKoo Cat#: 581564 | Name: T-2 triol

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

T-2 Mycotoxin is a trichothecene mycotoxin. It is a naturally occurring mold byproduct of Fusarium spp. fungus which is toxic to humans and animals.

Chemical Structure

T-2 triol

CAS#34114-98-2

Theoretical Analysis

MedKoo Cat#: 581564

Name: T-2 triol

CAS#: 34114-98-2

Chemical Formula: C20H30O7

Exact Mass: 382.1992

Molecular Weight: 382.45

Elemental Analysis: C, 62.81; H, 7.91; O, 29.28

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 650.00	Back order
10mg	USD 1,500.00	2 Weeks

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Related CAS #

No Data

Synonym

T-2 triol; Toxin T-2 triol; Deacetyl-HT-2 toxin

IUPAC/Chemical Name

12,13-Epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol 8-isovalerate

InChi Key

DDAUKBBLCGQHIP-CAVDVMKYSA-N

InChi Code

InChI=1S/C20H30O7/c1-10(2)5-14(22)26-12-7-19(8-21)13(6-11(12)3)27-17-15(23)16(24)18(19,4)20(17)9-25-20/h6,10,12-13,15-17,21,23-24H,5,7-9H2,1-4H3/t12-,13+,15+,16+,17+,18+,19+,20-/m0/s1

SMILES Code

C[C@@]12[C@H](O)[C@@H](O)[C@H]([C@@]23CO3)O[C@]4([H])C=C(C)[C@@H](OC(CC(C)C)=O)C[C@]14CO

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 382.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Investigating the Impact of Dietary Fibers on Mycotoxin Bioaccessibility during In Vitro Biscuit Digestion and Metabolites Identification. Foods. 2023 Aug 23;12(17):3175. doi: 10.3390/foods12173175. PMID: 37685107; PMCID: PMC10486935. 5: Narváez A, Izzo L, Pallarés N, Castaldo L, Rodríguez-Carrasco Y, Ritieni A. Human Biomonitoring of T-2 Toxin, T-2 Toxin-3-Glucoside and Their Metabolites in Urine through High-Resolution Mass Spectrometry. Toxins (Basel). 2021 Dec 5;13(12):869. doi: 10.3390/toxins13120869. PMID: 34941707; PMCID: PMC8703800. 6: De Colli L, De Ruyck K, Abdallah MF, Finnan J, Mullins E, Kildea S, Spink J, Elliott C, Danaher M. Natural Co-Occurrence of Multiple Mycotoxins in Unprocessed Oats Grown in Ireland with Various Production Systems. Toxins (Basel). 2021 Mar 4;13(3):188. doi: 10.3390/toxins13030188. PMID: 33806558; PMCID: PMC7998419. 7: Ulrich S, Gottschalk C, Biermaier B, Bahlinger E, Twarużek M, Asmussen S, Schollenberger M, Valenta H, Ebel F, Dänicke S. Occurrence of type A, B and D trichothecenes, zearalenone and stachybotrylactam in straw. Arch Anim Nutr. 2021 Apr;75(2):105-120. doi: 10.1080/1745039X.2021.1877075. Epub 2021 Feb 21. PMID: 33615927. 8: Taroncher M, Rodríguez-Carrasco Y, Ruiz MJ. Interactions between T-2 toxin and its metabolites in HepG2 cells and in silico approach. Food Chem Toxicol. 2021 Feb;148:111942. doi: 10.1016/j.fct.2020.111942. Epub 2020 Dec 28. PMID: 33359025. 9: Piacenza N, Kaltner F, Maul R, Gareis M, Schwaiger K, Gottschalk C. Distribution of T-2 toxin and HT-2 toxin during experimental feeding of yellow mealworm (Tenebrio molitor). Mycotoxin Res. 2021 Feb;37(1):11-21. doi: 10.1007/s12550-020-00411-x. Epub 2020 Sep 29. PMID: 32990831; PMCID: PMC7819947. 10: Taroncher M, Rodríguez-Carrasco Y, Ruiz MJ. T-2 toxin and its metabolites: Characterization, cytotoxic mechanisms and adaptive cellular response in human hepatocarcinoma (HepG2) cells. Food Chem Toxicol. 2020 Nov;145:111654. doi: 10.1016/j.fct.2020.111654. Epub 2020 Aug 7. PMID: 32777337. 11: Kasimir M, Behrens M, Schulz M, Kuchenbuch H, Focke C, Humpf HU. Intestinal Metabolism of α- and β-Glucosylated Modified Mycotoxins T-2 and HT-2 Toxin in the Pig Cecum Model. J Agric Food Chem. 2020 May 13;68(19):5455-5461. doi: 10.1021/acs.jafc.0c00576. Epub 2020 Apr 29. PMID: 32298583. 12: Ling A, Sun L, Guo W, Sun S, Yang J, Zhao Z. Individual and combined cytotoxic effects of T-2 toxin and its four metabolites on porcine Leydig cells. Food Chem Toxicol. 2020 May;139:111277. doi: 10.1016/j.fct.2020.111277. Epub 2020 Mar 23. PMID: 32217092. 13: Michlmayr H, Varga E, Malachová A, Fruhmann P, Piątkowska M, Hametner C, Šofrová J, Jaunecker G, Häubl G, Lemmens M, Berthiller F, Adam G. UDP- Glucosyltransferases from Rice, Brachypodium, and Barley: Substrate Specificities and Synthesis of Type A and B Trichothecene-3-O-β-d-glucosides. Toxins (Basel). 2018 Mar 6;10(3):111. doi: 10.3390/toxins10030111. PMID: 29509722; PMCID: PMC5869399. 14: Gao X, Mu P, Wen J, Sun Y, Chen Q, Deng Y. Detoxification of trichothecene mycotoxins by a novel bacterium, Eggerthella sp. DII-9. Food Chem Toxicol. 2018 Feb;112:310-319. doi: 10.1016/j.fct.2017.12.066. Epub 2017 Dec 30. PMID: 29294345. 15: Broekaert N, Devreese M, De Boevre M, De Saeger S, Croubels S. T-2 Toxin-3α-glucoside in Broiler Chickens: Toxicokinetics, Absolute Oral Bioavailability, and in Vivo Hydrolysis. J Agric Food Chem. 2017 Jun 14;65(23):4797-4803. doi: 10.1021/acs.jafc.7b00698. Epub 2017 May 31. PMID: 28520442. 16: Bernhardt K, Valenta H, Kersten S, Humpf HU, Dänicke S. Determination of T-2 toxin, HT-2 toxin, and three other type A trichothecenes in layer feed by high- performance liquid chromatography-tandem mass spectrometry (LC- MS/MS)--comparison of two sample preparation methods. Mycotoxin Res. 2016 May;32(2):89-97. doi: 10.1007/s12550-016-0244-z. Epub 2016 Mar 4. PMID: 26940912. 17: Góral T, Stuper-Szablewska K, Buśko M, Boczkowska M, Walentyn-Góral D, Wiśniewska H, Perkowski J. Relationships between Genetic Diversity and Fusarium Toxin Profiles of Winter Wheat Cultivars. Plant Pathol J. 2015 Sep;31(3):226-44. doi: 10.5423/PPJ.OA.03.2015.0038. Epub 2015 Sep 30. PMID: 26361471; PMCID: PMC4564148. 18: Yang S, Wang Y, Beier RC, Zhang H, De Ruyck K, Sun F, Cao X, Shen J, Zhang S, Wang Z. Simultaneous Determination of Type A and B Trichothecenes and Their Main Metabolites in Food Animal Tissues by Ultraperformance Liquid Chromatography Coupled with Triple-Quadrupole Mass Spectrometry. J Agric Food Chem. 2015 Sep 30;63(38):8592-600. doi: 10.1021/acs.jafc.5b03281. Epub 2015 Sep 16. PMID: 26321427. 19: Sun YX, Yao X, Shi SN, Zhang GJ, Xu LX, Liu YJ, Fang BH. Toxicokinetics of T-2 toxin and its major metabolites in broiler chickens after intravenous and oral administration. J Vet Pharmacol Ther. 2015 Feb;38(1):80-5. doi: 10.1111/jvp.12142. Epub 2014 Jul 31. PMID: 25079675. 20: Rubert J, León N, Sáez C, Martins CP, Godula M, Yusà V, Mañes J, Soriano JM, Soler C. Evaluation of mycotoxins and their metabolites in human breast milk using liquid chromatography coupled to high resolution mass spectrometry. Anal Chim Acta. 2014 Apr 11;820:39-46. doi: 10.1016/j.aca.2014.02.009. Epub 2014 Feb 12. PMID: 24745736.