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MedKoo Cat#: 555347 | Name: UAMC-3203 HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

UAMC-3203 is a Ferroptosis Inhibitor wtih IC50 = 12 nM. UAMC-3203 showed an improved protection compared to Fer-1 against multiorgan injury in mice. No toxicity was observed in mice after daily injection of UAMC-3203 for 4 weeks. UAMC-3203 inserts rapidly in a phospholipid bilayer in silico, which aligns with the current understanding of the mechanism of action of these compounds. In conclusion, these analogues have superior properties compared to Fer-1, show in vivo efficacy, and represent novel lead compounds with therapeutic potential in relevant ferroptosis-driven disease models.

Chemical Structure

UAMC-3203 HCl
UAMC-3203 HCl
CAS#2271358-65-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 555347

Name: UAMC-3203 HCl

CAS#: 2271358-65-5 (HCl)

Chemical Formula: C25H38ClN5O2S

Exact Mass: 0.0000

Molecular Weight: 508.12

Elemental Analysis: C, 59.10; H, 7.54; Cl, 6.98; N, 13.78; O, 6.30; S, 6.31

Price and Availability

Size Price Availability Quantity
5mg USD 90.00 2 Weeks
10mg USD 150.00 2 Weeks
25mg USD 250.00 2 Weeks
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 1,950.00 2 Weeks
1g USD 2,950.00 2 Weeks
2g USD 5,250.00 2 Weeks
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Related CAS #
2271358-65-5 (HCl) 2271358-64-4 (free base)
Synonym
UAMC-3203 HCl; UAMC-3203 hydrochloride; UAMC-3203; UAMC 3203; UAMC3203;
IUPAC/Chemical Name
3-(Benzylamino)-4-(cyclohexylamino)-N-(2-(piperazin-1-yl)-ethyl)benzenesulfonamide Hydrochloride
InChi Key
WBZHHIZXEXJBSM-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H37N5O2S.ClH/c31-33(32,28-15-18-30-16-13-26-14-17-30)23-11-12-24(29-22-9-5-2-6-10-22)25(19-23)27-20-21-7-3-1-4-8-21;/h1,3-4,7-8,11-12,19,22,26-29H,2,5-6,9-10,13-18,20H2;1H
SMILES Code
O=S(C1=CC=C(NC2CCCCC2)C(NCC3=CC=CC=C3)=C1)(NCCN4CCNCC4)=O.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Ferroptosis is an iron-catalyzed, nonapoptotic form of regulated necrosis that results in oxidative lipid damage in cell membranes that can be inhibited by the radical-trapping antioxidant Ferrostatin-1 (Fer-1).

Preparing Stock Solutions

The following data is based on the product molecular weight 508.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kan S, Feng S, Zhao X, Chen Z, Zhou M, Liu L, Zhu H, Cheng Y, Fu X, Hu W, Zhu R. UAMC-3203 inhibits ferroptosis and promotes functional recovery in rats with spinal cord injury. Sci Rep. 2024 Aug 30;14(1):20180. doi: 10.1038/s41598-024-70926-1. Erratum in: Sci Rep. 2024 Nov 14;14(1):28060. doi: 10.1038/s41598-024-78546-5. PMID: 39215144; PMCID: PMC11364804. 2: Balla A, Tran B, Valtari A, Steven P, Scarpellini C, Augustyns K, Urtti A, Vellonen KS, Ruponen M. A Novel Ferroptosis Inhibitor UAMC-3203, a Potential Treatment for Corneal Epithelial Wound. Pharmaceutics. 2022 Dec 29;15(1):118. doi: 10.3390/pharmaceutics15010118. PMID: 36678747; PMCID: PMC9863691. 3: Jin T, He Q, Cheng C, Li H, Liang L, Zhang G, Su C, Xiao Y, Bradley J, Peberdy MA, Ornato JP, Tang W. UAMC-3203 or/and Deferoxamine Improve Post- Resuscitation Myocardial Dysfunction Through Suppressing Ferroptosis in a Rat Model of Cardiac Arrest. Shock. 2022 Mar 1;57(3):344-350. doi: 10.1097/SHK.0000000000001869. PMID: 34618729; PMCID: PMC8868183. 4: Kan S, Feng S, Zhao X, Chen Z, Zhou M, Liu L, Zhu H, Cheng Y, Fu X, Hu W, Zhu R. Author Correction: UAMC-3203 inhibits ferroptosis and promotes functional recovery in rats with spinal cord injury. Sci Rep. 2024 Nov 14;14(1):28060. doi: 10.1038/s41598-024-78546-5. Erratum for: Sci Rep. 2024 Aug 30;14(1):20180. doi: 10.1038/s41598-024-70926-1. PMID: 39543269; PMCID: PMC11564897. 5: Puylaert P, Roth L, Van Praet M, Pintelon I, Dumitrascu C, van Nuijs A, Klejborowska G, Guns PJ, Berghe TV, Augustyns K, De Meyer GRY, Martinet W. Effect of erythrophagocytosis-induced ferroptosis during angiogenesis in atherosclerotic plaques. Angiogenesis. 2023 Nov;26(4):505-522. doi: 10.1007/s10456-023-09877-6. Epub 2023 Apr 29. PMID: 37120604; PMCID: PMC10542744. 6: Van San E, Debruyne AC, Veeckmans G, Tyurina YY, Tyurin VA, Zheng H, Choi SM, Augustyns K, van Loo G, Michalke B, Venkataramani V, Toyokuni S, Bayir H, Vandenabeele P, Hassannia B, Vanden Berghe T. Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression. Cell Death Differ. 2023 Sep;30(9):2092-2103. doi: 10.1038/s41418-023-01195-0. Epub 2023 Aug 4. PMID: 37542104; PMCID: PMC10482919. 7: Ryan F, Blex C, Ngo TD, Kopp MA, Michalke B, Venkataramani V, Curran L, Schwab JM, Ruprecht K, Otto C, Jhelum P, Kroner A, David S. Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury. Acta Neuropathol. 2024 Jun 22;147(1):106. doi: 10.1007/s00401-024-02758-2. PMID: 38907771; PMCID: PMC11193702. 8: Adelusi OB, Etemadi Y, Akakpo JY, Ramachandran A, Jaeschke H. Effect of ferroptosis inhibitors in a murine model of acetaminophen-induced liver injury. J Biochem Mol Toxicol. 2024 Aug;38(8):e23791. doi: 10.1002/jbt.23791. PMID: 39082238; PMCID: PMC11382325. 9: Peleman C, Hellemans S, Veeckmans G, Arras W, Zheng H, Koeken I, Van San E, Hassannia B, Walravens M, Kayirangwa E, Beyene NT, Van Herck MA, De Vos WH, Pintelon I, van Nassauw L, Oosterlinck B, Smet A, Vits L, Dirinck E, Verrijken A, De Man J, Van Eyck A, Kwanten WJ, Vonghia L, Driessen A, Augustyns K, Toyokuni S, De Winter B, Van Steenkiste C, Francque S, Vanden Berghe T. Ferroptosis is a targetable detrimental factor in metabolic dysfunction- associated steatotic liver disease. Cell Death Differ. 2024 Sep;31(9):1113-1126. doi: 10.1038/s41418-024-01348-9. Epub 2024 Jul 26. PMID: 39060422; PMCID: PMC11369286. 10: Horinouchi T, Mazaki Y, Miwa S. Mechanism of cytotoxicity induced by the cigarette smoke extract (CSE) of heated tobacco products in vascular smooth muscle cells: A comparative study of the cytotoxic effects of CSE and the ferroptosis inducer, erastin. J Pharmacol Sci. 2024 Feb;154(2):86-96. doi: 10.1016/j.jphs.2023.12.010. Epub 2023 Dec 27. PMID: 38246732.

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