Scutellarein | CAS#529-53-3

MedKoo Cat#: 330163 | Name: Scutellarein

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Scutellarein is natural product. Scutellarein from Scutellaria barbata induces apoptosis of human colon cancer HCT116 cells through the ROS-mediated mitochondria-dependent pathway. Scutellarein Reduces Inflammatory Responses by Inhibiting Src Kinase Activity.

Chemical Structure

Scutellarein

CAS#529-53-3

Theoretical Analysis

MedKoo Cat#: 330163

Name: Scutellarein

CAS#: 529-53-3

Chemical Formula: C15H10O6

Exact Mass: 286.0477

Molecular Weight: 286.24

Elemental Analysis: C, 62.94; H, 3.52; O, 33.54

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 400.00	2 weeks
50mg	USD 900.00	2 weeks

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Synonym

Scutellarein; 4',5,6,7-Tetrahydroxyflavone;

IUPAC/Chemical Name

5,6,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

InChi Key

JVXZRQGOGOXCEC-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)11-5-9(17)13-12(21-11)6-10(18)14(19)15(13)20/h1-6,16,18-20H

SMILES Code

O=C1C=C(C2=CC=C(O)C=C2)OC3=C1C(O)=C(O)C(O)=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC50s = 12 and 0.86 μM, respectively). It decreases NO release and mRNA expression of iNOS and TNF-α induced by LPS in RAW 264.7 macrophages. Scutellarein decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.

In vitro activity:

Scutellarein can be used to treat inflammation. In lipopolysaccharide stimulated RAW264.7 cells, scutellarein treatment reduced p-JNK, p-ERK, and iNOS, but there was no change in expression of COX-2. Reference: Molecules. 2022 Jun 12;27(12):3782. https://pubmed.ncbi.nlm.nih.gov/35744907/

In vivo activity:

Scutellarein is a potential for atopic dermatitis by inhibiting TRPV3, and TRPV3, which ameliorates carvacrol-induced skin inflammation. In 2,4-dinitrofluorobenzene (DNFB) and carvacrol-induced dermatitis mouse models, subcutaneous administration of Scutellarein suppressed DNFB and carvacrol-induced pruritus, epidermal hyperplasia, and skin inflammation in wild type mice but had no additional benefit in Trpv3 knockout mice in the carvacrol model. Reference: Br J Pharmacol. 2022 Oct;179(20):4792-4808. https://pubmed.ncbi.nlm.nih.gov/35771623/

	Solvent	mg/mL	mM
Solubility
	DMF	20.0	69.87
	DMSO	20.0	69.87
	Ethanol	0.2	0.70

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 286.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Park MY, Ha SE, Kim HH, Bhosale PB, Abusaliya A, Jeong SH, Park JS, Heo JD, Kim GS. Scutellarein Inhibits LPS-Induced Inflammation through NF-κB/MAPKs Signaling Pathway in RAW264.7 Cells. Molecules. 2022 Jun 12;27(12):3782. doi: 10.3390/molecules27123782. PMID: 35744907; PMCID: PMC9227861. 2. Chen Q, Shang C, Han M, Chen C, Tang W, Liu W. Inhibitory mechanism of scutellarein on tyrosinase by kinetics, spectroscopy and molecular simulation. Spectrochim Acta A Mol Biomol Spectrosc. 2023 Aug 5;296:122644. doi: 10.1016/j.saa.2023.122644. Epub 2023 Mar 21. PMID: 36963278. 3. Liu L, Zhang Y, Wang L, Liu Y, Chen H, Hu Q, Xie C, Meng X, Shen X. Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase. Phytother Res. 2023 Oct;37(10):4587-4606. doi: 10.1002/ptr.7928. Epub 2023 Jun 24. PMID: 37353982. 4. Wang Y, Tan L, Jiao K, Xue C, Tang Q, Jiang S, Ren Y, Chen H, El-Aziz TMA, Abdelazeem KNM, Yu Y, Zhao F, Zhu MX, Cao Z. Scutellarein attenuates atopic dermatitis by selectively inhibiting transient receptor potential vanilloid 3 channels. Br J Pharmacol. 2022 Oct;179(20):4792-4808. doi: 10.1111/bph.15913. Epub 2022 Jul 21. PMID: 35771623.

In vitro protocol:

In vivo protocol:

1. Liu L, Zhang Y, Wang L, Liu Y, Chen H, Hu Q, Xie C, Meng X, Shen X. Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15-lipoxygenase. Phytother Res. 2023 Oct;37(10):4587-4606. doi: 10.1002/ptr.7928. Epub 2023 Jun 24. PMID: 37353982. 2. Wang Y, Tan L, Jiao K, Xue C, Tang Q, Jiang S, Ren Y, Chen H, El-Aziz TMA, Abdelazeem KNM, Yu Y, Zhao F, Zhu MX, Cao Z. Scutellarein attenuates atopic dermatitis by selectively inhibiting transient receptor potential vanilloid 3 channels. Br J Pharmacol. 2022 Oct;179(20):4792-4808. doi: 10.1111/bph.15913. Epub 2022 Jul 21. PMID: 35771623.

1: Song Y, Lv H, Xu L, Liu Z, Wang J, Fang T, Deng X, Zhou Y, Li D. In vitro and in vivo activities of scutellarein, a novel polyphosphate kinase 1 inhibitor against Acinetobacter baumannii infection. Microb Cell Fact. 2024 Oct 8;23(1):269. doi: 10.1186/s12934-024-02540-9. PMID: 39379932; PMCID: PMC11462863. 2: Martynyuk VA, Efimova SS, Malykhina AI, Ostroumova OS. The effects of plant flavones on the membrane boundary potential and lipid packing stress. Colloids Surf B Biointerfaces. 2024 Sep 24;245:114269. doi: 10.1016/j.colsurfb.2024.114269. Epub ahead of print. PMID: 39341052. 3: Zhao S, Xiao S, Wang W, Dong X, Liu X, Wang Q, Jiang Y, Wu W. Network pharmacology and transcriptomics reveal the mechanisms of FFBZL in the treatment of oral squamous cell carcinoma. Front Pharmacol. 2024 Sep 11;15:1405596. doi: 10.3389/fphar.2024.1405596. PMID: 39323640; PMCID: PMC11422709. 4: Sharma S, Choudhary M, Sharma O, Injeti E, Mittal A. Mechanistic insights into antidiabetic potential of Ficus viren against multi organ specific diabetic targets: molecular docking, MDS, MM-GBSA analysis. Comput Biol Chem. 2024 Aug 28;113:108185. doi: 10.1016/j.compbiolchem.2024.108185. Epub ahead of print. PMID: 39217892. 5: Sruthi D, John Zachariah T. Volatile and non-volatile metabolite profiling of under-explored crop Piper colubrinum Link. with chromatography mass spectrometry approach and its biochemical diversity from medicinally valued Piper species. J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Sep 15;1245:124260. doi: 10.1016/j.jchromb.2024.124260. Epub 2024 Aug 3. PMID: 39178608. 6: Chen J, He Z, Luo K, Luo Q, Wang Y, Liu T, Li L, Dai Z, Yang S, Li Y, Zhao Y, Tang L, Fu X. Scutellarein derivatives with histamine H3 receptor antagonism and cholinesterase inhibitory potency as multi target-directed ligands for possible Alzheimer's disease therapy. Bioorg Chem. 2024 Oct;151:107704. doi: 10.1016/j.bioorg.2024.107704. Epub 2024 Aug 8. PMID: 39126870. 7: Wei W, Si Y, Li Z, Yin X, Ma G, Shi J, Li C, Yu L, Zheng W, Wang Y, Liu K, Xu R, Cui S. Exploring the potential mechanism of Chinese herbal medicine Fuzi on aplastic anemia based on UHPLC-MS/MS method combined with network pharmacology and molecular docking. Nat Prod Res. 2024 Aug 6:1-9. doi: 10.1080/14786419.2024.2386126. Epub ahead of print. PMID: 39105448. 8: Yırtıcı Ü. Natural flavonoids as promising lactate dehydrogenase A inhibitors: Comprehensive in vitro and in silico analysis. Arch Pharm (Weinheim). 2024 Sep;357(9):e2400455. doi: 10.1002/ardp.202400455. Epub 2024 Jul 25. PMID: 39054614. 9: Zhang X, Zhang Y, Wang N, Liu J, Zhang LT, Zhang ZQ, Li DQ. The mysteries of pharmacokinetics and in vivo metabolism of Oroxylum indicum (L.) Kurz: A new perspective from MSOP method. Heliyon. 2024 Jun 19;10(12):e33234. doi: 10.1016/j.heliyon.2024.e33234. PMID: 39027462; PMCID: PMC11254595. 10: Demiroz Akbulut T, Demir S, Alsakini KAMH, Nalbantsoy A, Baykan S. Anti- inflammatory phenolic glycosides from endemic Marrubium rotundifolium Boiss. Nat Prod Res. 2024 Jul 17:1-9. doi: 10.1080/14786419.2024.2379011. Epub ahead of print. PMID: 39015030. 11: Qin XY, Zhu R, Hou XD, Zhu GH, Zhang M, Fan YF, Qi SL, Huang J, Tang H, Wang P, Ge GB. Discovery of baicalein derivatives as novel inhibitors against human pancreatic lipase: Structure-activity relationships and inhibitory mechanisms. Int J Biol Macromol. 2024 Aug;275(Pt 1):133523. doi: 10.1016/j.ijbiomac.2024.133523. Epub 2024 Jun 29. PMID: 38945336. 12: Li X, Zhang X, Kang Y, Cai M, Yan J, Zang C, Gao Y, Qi Y. Scutellarein Suppresses the Production of ROS and Inflammatory Mediators of LPS-Activated Bronchial Epithelial Cells and Attenuates Acute Lung Injury in Mice. Antioxidants (Basel). 2024 Jun 12;13(6):710. doi: 10.3390/antiox13060710. PMID: 38929149; PMCID: PMC11200809. 13: Lai J, Li C. Review on the pharmacological effects and pharmacokinetics of scutellarein. Arch Pharm (Weinheim). 2024 Sep;357(9):e2400053. doi: 10.1002/ardp.202400053. Epub 2024 Jun 7. PMID: 38849327. 14: Thrigulla SR, Singh G, Soni H, Tandon S, Koulgi S, Uppuladinne MVN, Jani V, Sonavane U, Joshi R, Gandhi Y, Kumar V, Charde V, Mishra SK, Chincholikar M, Narayan R, Lavaniya V, Narasimhaji CV, Srikanth N, Acharya R. In-silico evaluation of Oroxylum indicum vent compounds in the plausible treatment and prevention of nasopharyngeal cancer. J Ayurveda Integr Med. 2024 May- Jun;15(3):100986. doi: 10.1016/j.jaim.2024.100986. Epub 2024 May 27. PMID: 38805854; PMCID: PMC11153917. 15: Malykhina AI, Efimova SS, Andriianov VS, Ostroumova OS. The interaction of plant flavones with amphotericin B: Consequences for its pore-forming ability. Biomed Pharmacother. 2024 Jun;175:116723. doi: 10.1016/j.biopha.2024.116723. Epub 2024 May 9. Erratum in: Biomed Pharmacother. 2024 Jul;176:116890. doi: 10.1016/j.biopha.2024.116890. PMID: 38723514. 16: Ye Z, Ge Z, Yang S, Hu T, Ye Q, Chen H. Scutellarein alleviates osteoarthritis progression through the PI3K/Akt/NF-kappaB signaling pathway: In vitro and in vivo studies. Phytother Res. 2024 Jul;38(7):3509-3524. doi: 10.1002/ptr.8232. Epub 2024 May 2. PMID: 38695125. 17: Zeng Z, Zhang C, Hu J, Wang F, Wu Z, Wang J, Zhang J, Yang S, Chen J, Li M, Tong Q, Qiu S, Chen W. Rapid characterization of non-volatile phenolic compounds reveals the reliable chemical markers for authentication of traditional Chinese medicine Xiang-ru among confusing Elsholtzia species. Chin J Nat Med. 2024 Apr;22(4):375-384. doi: 10.1016/S1875-5364(24)60614-X. PMID: 38658100. 18: Thoa NT, Son NT. Scutellarein: a review of chemistry and pharmacology. J Pharm Pharmacol. 2024 Apr 5:rgae039. doi: 10.1093/jpp/rgae039. Epub ahead of print. PMID: 38579142. 19: Jing SZ, Yang SH, Qu YK, Hao HH, Wu H. Scutellarein Ameliorated Chondrocyte Inflammation and Osteoarthritis in Rats. Curr Med Sci. 2024 Apr;44(2):355-368. doi: 10.1007/s11596-024-2854-6. Epub 2024 Apr 4. PMID: 38570439. 20: Lan Y, Tian F, Tang H, Pu P, He Q, Duan L. Food therapy of scutellarein ameliorates pirarubicin‑induced cardiotoxicity in rats by inhibiting apoptosis and ferroptosis through regulation of NOX2‑induced oxidative stress. Mol Med Rep. 2024 May;29(5):84. doi: 10.3892/mmr.2024.13208. Epub 2024 Mar 22. PMID: 38516760; PMCID: PMC10979251.