MedKoo Cat#: 573128 | Name: Ambazone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ambazone is an antiseptic agent with potential antibacterial and antileukemic activity. Although the exact mechanism of action remains unclear, ambazone appears to interfere with the membrane-bound nucleotide system by increasing the intracellular concentration of cAMP in leukemia cells and macrophages, which potentially contributes to this agent's antineoplastic activity.

Chemical Structure

Ambazone
Ambazone
CAS#539-21-9

Theoretical Analysis

MedKoo Cat#: 573128

Name: Ambazone

CAS#: 539-21-9

Chemical Formula: C8H11N7S

Exact Mass: 237.0797

Molecular Weight: 237.29

Elemental Analysis: C, 40.49; H, 4.67; N, 41.32; S, 13.51

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Related CAS #
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Synonym
Ambazone
IUPAC/Chemical Name
1,4-Benzoquinone guanylhydrazone thiosemicarbazone
InChi Key
MLMFUKWWZIZRHX-UWRPRBHNSA-N
InChi Code
1S/C8H11N7S/c9-7(10)14-12-5-1-3-6(4-2-5)13-15-8(11)16/h1-4H,(H4,9,10,14)(H3,11,15,16)/b12-5-,13-6+
SMILES Code
C1=C\C(=N\NC(=N)N)C=C\C1=N\NC(=S)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 237.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fulga I, Neguţ M, Năşcuţiu AM, Nemet C, Toma F, Grigore L, Niţescu R, Marcu C, Nedelcu L, Spircu T. [Microbial sensitivity to ambazone (Faringosept) in pharyngeal samples from patients with acute infections of the upper respiratory tract]. Bacteriol Virusol Parazitol Epidemiol. 2007 Jan-Jun;52(1-2):19-27. Romanian. PubMed PMID: 18441955. 2: Löber G, Hoffmann H. Ambazone as a membrane active antitumor drug. Biophys Chem. 1990 Apr;35(2-3):287-300. Review. PubMed PMID: 2204445. 3: Janke B. [The effect of ambazone and ambazone derivatives on immunologic processes in human lymphocytes]. Pharmazie. 1990 Feb;45(2):126-7. German. PubMed PMID: 2339169. 4: Baumgart J, Wisniewski HG, Amlacher R, Zhukovskaya NV, Rentz E. Age-dependent antileukemic action and suppression of immune response by 1,4-benzoquinone-guanylhydrazone-thiosemicarbazone (ambazone) in mice. Neoplasma. 1989;36(4):393-400. PubMed PMID: 2770926.