Synonym
Phenylmercuriurea; Abavit; Acrox; Leytosan; NSC 310159; NSC310159; NSC-310159
IUPAC/Chemical Name
phenyl(ureido)mercury
InChi Key
UNQDVBLGFWIFGX-UHFFFAOYSA-M
InChi Code
InChI=1S/C6H5.CH4N2O.Hg/c1-2-4-6-5-3-1;2-1(3)4;/h1-5H;(H4,2,3,4);/q;;+1/p-1
SMILES Code
O=C(N)N[Hg]C1=CC=CC=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
336.74
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Honeycutt RC, Krogmann DW. Inhibition of chloroplast reactions with phenylmercuric acetate. Plant Physiol. 1972 Mar;49(3):376-80. PubMed PMID: 16657964; PubMed Central PMCID: PMC365968.
2: Poole LB, Claiborne A. The non-flavin redox center of the streptococcal NADH peroxidase. I. Thiol reactivity and redox behavior in the presence of urea. J Biol Chem. 1989 Jul 25;264(21):12322-9. PubMed PMID: 2501302.
3: Satoh K, Katoh S. Two electrogenic mechanisms contributing to the 560 nm absorption changes in intact Bryopsis chloroplasts. Biochim Biophys Acta. 1979 Mar 15;545(3):454-65. PubMed PMID: 427138.
4: Bernstein GS. Physiological aspects of vaginal contraception. Contraception. 1974 Apr;9(4):333-45. Review. PubMed PMID: 4613535.
5: Itoh M, Masuda K, Ito Y, Akizawa T, Yoshioka M, Imai K, Okada Y, Sato H, Seiki M. Purification and refolding of recombinant human proMMP-7 (pro-matrilysin) expressed in Escherichia coli and its characterization. J Biochem. 1996 Apr;119(4):667-73. PubMed PMID: 8743567.
6: Yasumitsu H, Miyazaki K, Umenishi F, Koshikawa N, Umeda M. Comparison of extracellular matrix-degrading activities between 64-kDa and 90-kDa gelatinases purified in inhibitor-free forms from human schwannoma cells. J Biochem. 1992 Jan;111(1):74-80. PubMed PMID: 1318881.
7: Dastychová E, Necas M, Vasku V. Contact hypersensitivity to selected excipients of dermatological topical preparations and cosmetics in patients with chronic eczema. Acta Dermatovenerol Alp Pannonica Adriat. 2008 Jun;17(2):61-8. PubMed PMID: 18709291.
8: Verkman AS, Lukacovic MF, Tinklepaugh MS, Dix JA. Quenching of red cell tryptophan fluorescence by mercurial compounds. Membr Biochem. 1986;6(4):269-89. PubMed PMID: 3574139.
9: Dastychová E, Necas M, Pĕncíková K, Cerný P. [Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations]. Ceska Slov Farm. 2004 May;53(3):151-6. Czech. PubMed PMID: 15218738.
10: Perkins J, Bertino JR. STIMULATION OF DIHYDROFOLATE REDUCTASE ACTIVITY BY p-CHLOROMERCURIBENZOATE. Biochem Biophys Res Commun. 1964 Mar 9;15(2):121-6. PubMed PMID: 26410903.
11: Ansermet F, Mieville C, Diezi J. Urinary enzyme excretion and changes in renal functions induced by toxic substances or by renal ischemia in rats. Arch Toxicol Suppl. 1980;4:201-7. PubMed PMID: 6933903.
12: Hanna MM, Meares CF. Synthesis of a cleavable dinucleotide photoaffinity probe of ribonucleic acid polymerase: application to trinucleotide labeling of an Escherichia coli transcription complex. Biochemistry. 1983 Jul 19;22(15):3546-51. PubMed PMID: 6351906.