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MedKoo Cat#: 564275 | Name: SRI-36160

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SRI-36160 is a potent inhibitor of Wn/ß-catenin signaling in cancer cells.

Chemical Structure

SRI-36160
CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564275

Name: SRI-36160

CAS#: NONE

Chemical Formula: C18H17Cl2N3

Exact Mass: 345.0800

Molecular Weight: 346.26

Elemental Analysis: C, 62.44; H, 4.95; Cl, 20.48; N, 12.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SRI36160; SRI 36160; SRI-36160
IUPAC/Chemical Name
5,6-Dichloro-2-(4-piperidin-1-yl-phenyl)-1H-benzoimidazole
InChi Key
GCHIDGDINQWQIJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H17Cl2N3/c19-14-10-16-17(11-15(14)20)22-18(21-16)12-4-6-13(7-5-12)23-8-2-1-3-9-23/h4-7,10-11H,1-3,8-9H2,(H,21,22)
SMILES Code
ClC1=C(Cl)C=C2N=C(C3=CC=C(N4CCCCC4)C=C3)NC2=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 346.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li Y, Oliver PG, Lu W, Pathak V, Sridharan S, Augelli-Szafran CE, Buchsbaum DJ, Suto MJ. Retraction notice to "SRI36160 is a specific inhibitor of Wnt/-catenin signaling in human pancreatic and colorectal cancer cells" [Canc. Lett. 389C (2017) 41-48]. Cancer Lett. 2018 May 28;422:131. doi: 10.1016/j.canlet.2018.03.017. PubMed PMID: 29579438; PubMed Central PMCID: PMC5991086. 2: Li Y, Oliver PG, Lu W, Pathak V, Sridharan S, Augelli-Szafran CE, Buchsbaum DJ, Suto MJ. SRI36160 is a specific inhibitor of Wnt/β-catenin signaling in human pancreatic and colorectal cancer cells. Cancer Lett. 2017 Mar 28;389:41-48. doi: 10.1016/j.canlet.2016.12.030. Epub 2016 Dec 30. Retraction in: Cancer Lett. 2018 May 28;422:131. PubMed PMID: 28043913; PubMed Central PMCID: PMC5544029.

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