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MedKoo Cat#: 596563 | Name: Posatirelin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Posatirelin is a thyrotropin-releasing-hormone analogue. It stimulates oxygen consumption.

Chemical Structure

Posatirelin
Posatirelin
CAS#78664-73-0

Theoretical Analysis

MedKoo Cat#: 596563

Name: Posatirelin

CAS#: 78664-73-0

Chemical Formula: C17H28N4O4

Exact Mass: 352.2111

Molecular Weight: 352.43

Elemental Analysis: C, 57.94; H, 8.01; N, 15.90; O, 18.16

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Posatirelin; BRN 6006446; BRN-6006446; BRN6006446; Posatirelinum; RGH-2202; RGH 2202; RGH2202;
IUPAC/Chemical Name
(S)-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-4-methyl-1-oxopentan-2-yl)-6-oxopiperidine-2-carboxamide
InChi Key
DPNGIIPSQYKWQA-AVGNSLFASA-N
InChi Code
InChI=1S/C17H28N4O4/c1-10(2)9-12(17(25)21-8-4-6-13(21)15(18)23)20-16(24)11-5-3-7-14(22)19-11/h10-13H,3-9H2,1-2H3,(H2,18,23)(H,19,22)(H,20,24)/t11-,12-,13-/m0/s1
SMILES Code
O=C(N)[C@H]1N(C([C@H](CC(C)C)NC([C@H](CCC2)NC2=O)=O)=O)CCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 352.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Treatment of vascular dementia: evidence from trials with non-cholinergic drugs. J Neurol Sci. 2004 Nov 15;226(1-2):67-70. Review. PubMed PMID: 15537523. 4: Sarkadi A, Kárpáti E. [TRH analogs at Gedeon Richter Ltd.: highlights of experimental and clinical efficacy of posatirelin]. Acta Pharm Hung. 2002;72(1):62-8. Hungarian. PubMed PMID: 12426788. 5: Bodo M, Perjes G, Kalman E, Bacskai E, Berko K, Sarkadi A, Nagy I, Keim KL, Matysik FM, Csomor K, McCarron R, Zagvazdin Y, Rosenthal M, Morrissette C, Herendy E, Szporny L, Nagy Z. Screening for cerebroprotective agents using an in vivo model of cerebral reversible depolarization in awake rats. Pharmacol Res. 2001 Nov;44(5):419-29. PubMed PMID: 11712873. 6: Jaworska-Feil L, Kajta M, Budziszewska B, Leśkiewicz M, Lasoń W. Protective effects of TRH and its stable analogue, RGH-2202, on kainate-induced seizures and neurotoxicity in rodents. Epilepsy Res. 2001 Jan;43(1):67-73. PubMed PMID: 11137388. 7: Sabbatini M, Coppi G, Maggioni A, Olgiati V, Panocka I, Amenta F. Effect of lesions of the nucleus basalis magnocellularis and of treatment with posatirelin on cholinergic neurotransmission enzymes in the rat cerebral cortex. Mech Ageing Dev. 1998 Aug 14;104(2):183-94. PubMed PMID: 9792196. 8: Przewłocka B, Labuz D, Mika J, Lipkowski A, van Luijtelaar G, Coenen A, Lasoń W. Protective effects of TRH and its analogues in chemical and genetic models of seizures. Pol J Pharmacol. 1997 Sep-Oct;49(5):373-8. PubMed PMID: 9566039. 9: Amenta F, Sabbatini M, Coppi G, Maggioni A, Olgiati V, Panocka I. Effect of treatment with the neuroactive peptide posatirelin on microanatomical changes of frontal cortex and hippocampus caused by lesions of the locus coeruleus. Drugs Exp Clin Res. 1997;23(2):77-88. PubMed PMID: 9309383. 10: Panocka I, Coppi G, Maggioni A, Olgiati V, Sabbatini M, Amenta F. Effect of the thyrotropin releasing hormone analogue posatirelin (RGH 2202) on microanatomical changes induced by lesions of the nucleus basalis magnocellularis in the rat. Drugs Exp Clin Res. 1997;23(1):13-23. PubMed PMID: 9093818. 11: Reboldi G, Parnetti L, Santeusanio F, Ambrosoli L, Palumbo B, Cherubini A, Girardello R, Poli A, Lowenthal DT, Senin U. Pharmacokinetic profile and endocrine effects of posatirelin treatment in healthy elderly subjects. J Clin Pharmacol. 1996 Sep;36(9):823-31. PubMed PMID: 8889903. 12: Parnetti L, Ambrosoli L, Agliati G, Caratozzolo P, Fossati L, Frattola L, Martucci N, Murri L, Nappi G, Puca FM, Poli A, Girardello R, Senin U. Posatirelin in the treatment of vascular dementia: a double-blind multicentre study vs placebo. Acta Neurol Scand. 1996 Jun;93(6):456-63. PubMed PMID: 8836309. 13: Benzi G, Gorini A, Ghigini B, Moretti A, Dagani F, Villa RF. Is the Mg(2+)-ATP-dependent proton pumping activity of the synaptic vesicles a factor involved in the cerebral hypoxia? Neurochem Res. 1996 Jan;21(1):7-18. PubMed PMID: 8833218. 14: Drago F, Coppi G, Antonuzzo PA, Valerio C, Genazzani AA, Grassi M, Raffaele R, Scapagnini U. Effects of RGH 2202 on cognitive and motor behavior of the rat. Neurobiol Aging. 1996 Jan-Feb;17(1):67-71. PubMed PMID: 8786805. 15: Noda Y, Furukawa K, Kohayakawa H, Oka M. Effects of RGH-2202 on behavioral deficits after focal cerebral ischemia in rats. Pharmacol Biochem Behav. 1995 Dec;52(4):695-9. PubMed PMID: 8587907. 16: Parnetti L, Ambrosoli L, Abate G, Azzini C, Balestreri R, Bartorelli L, Bordin A, Crepaldi G, Cristianini G, Cucinotta D, et al. Posatirelin for the treatment of late-onset Alzheimer's disease: a double-blind multicentre study vs citicoline and ascorbic acid. Acta Neurol Scand. 1995 Aug;92(2):135-40. PubMed PMID: 7484061. 17: Pastoris O, Dossena M, Arnaboldi R, Gorini A, Villa RF. Age-related alterations of skeletal muscle metabolism by intermittent hypoxia and TRH-analogue treatment. Pharmacol Res. 1994 Aug-Sep;30(2):171-85. PubMed PMID: 7816745. 18: Voĭnov VA, Chichenkov ON, Chizh BA. [The mechanisms of the participation of the peptidergic systems in regulating respiratory center function]. Fiziol Zh Im I M Sechenova. 1993 Nov;79(11):31-7. Russian. PubMed PMID: 8162104. 19: Casabona G, Bruno V, Catania MV, Sortino MA, Nicoletti F, Scapagnini U, Canonico PL. Thyrotropin releasing hormone (TRH) and its analog, RGH-2202, accelerate maturation of cerebellar neurons in vitro. Brain Res Dev Brain Res. 1992 Oct 23;69(2):179-83. PubMed PMID: 1424094. 20: Drago F, Grassi M, Valerio C, Coppi G, Lauria N, Nicotra GC, Raffaele R. Behavioral changes induced by the thyrotropin-releasing hormone analogue, RGH 2202. Peptides. 1991 Nov-Dec;12(6):1309-13. PubMed PMID: 1815218.