Aloe emodin anthrone | CAS# 6247-99-0 | Stimulant-laxative

MedKoo Cat#: 573109 | Name: Aloe emodin anthrone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aloe emodin anthrone is a stimulant-laxative which has been shown to enhance colonic membrane permeability of water-soluble and poorly permeable compounds.

Chemical Structure

Aloe emodin anthrone

CAS#6247-99-0

Theoretical Analysis

MedKoo Cat#: 573109

Name: Aloe emodin anthrone

CAS#: 6247-99-0

Chemical Formula: C15H12O4

Exact Mass: 256.0736

Molecular Weight: 256.26

Elemental Analysis: C, 70.31; H, 4.72; O, 24.97

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

Aloe emodin anthrone

IUPAC/Chemical Name

9(10H)-Anthracenone, 1,8-dihydroxy-3-(hydroxymethyl)-

InChi Key

AVZIASIVCYCZND-UHFFFAOYSA-N

InChi Code

1S/C15H12O4/c16-7-8-4-10-6-9-2-1-3-11(17)13(9)15(19)14(10)12(18)5-8/h1-5,16-18H,6-7H2

SMILES Code

C1(c2c(cc(cc2O)CO)Cc2c1c(O)ccc2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 256.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Kai M, Hayashi K, Kaida I, Aki H, Yamamoto M. Permeation-enhancing effect of aloe-emodin anthrone on water-soluble and poorly permeable compounds in rat colonic mucosa. Biol Pharm Bull. 2002 Dec;25(12):1608-13. PubMed PMID: 12499649. 2: Yagi T, Yamauchi K, Kuwano S. The synergistic purgative action of aloe-emodin anthrone and rhein anthrone in mice: synergism in large intestinal propulsion and water secretion. J Pharm Pharmacol. 1997 Jan;49(1):22-5. PubMed PMID: 9120764. 3: Che QM, Akao T, Hattori M, Kobashi K, Namba T. Isolation of a human intestinal bacterium capable of transforming barbaloin to aloe-emodin anthrone. Planta Med. 1991 Feb;57(1):15-9. PubMed PMID: 2062951.