MedKoo Cat#: 573101 | Name: Aldoifosfamide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Aldoifosfamide is a metabolite of ifosfamide. Ifosfamide (also marketed as Mitoxana and Ifex) is a nitrogen mustard alkylating agent used in the treatment of cancer. It is sometimes abbreviated 'IFO''.

Chemical Structure

Aldoifosfamide
Aldoifosfamide
CAS#120144-70-9

Theoretical Analysis

MedKoo Cat#: 573101

Name: Aldoifosfamide

CAS#: 120144-70-9

Chemical Formula: C7H15Cl2N2O3P

Exact Mass: 276.0197

Molecular Weight: 277.08

Elemental Analysis: C, 30.34; H, 5.46; Cl, 25.59; N, 10.11; O, 17.32; P, 11.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Aldoifosfamide; UNII-S1JX147O5E; Mitoxana; Ifex
IUPAC/Chemical Name
3-Bis(2-chloroethylamino)phosphoryloxypropanal
InChi Key
IPTJZZUYNOWWHM-UHFFFAOYSA-N
InChi Code
1S/C7H15Cl2N2O3P/c8-2-4-10-15(13,11-5-3-9)14-7-1-6-12/h6H,1-5,7H2,(H2,10,11,13)
SMILES Code
ClCCNP(=O)(NCCCl)OCCC=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 277.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Voelcker G. Influence of the alkylating function of aldoifosfamide on the antitumor activity. Anticancer Drugs. 2017 Oct 3. doi: 10.1097/CAD.0000000000000569. [Epub ahead of print] PubMed PMID: 28984684. 2: Ludeman SM, Shulman-Roskes EM, Wong KK, Han SY, Anderson LW, Strong JM, Colvin OM. Oxime derivatives of the intermediary oncostatic metabolites of cyclophosphamide and ifosfamide: synthesis and deuterium labeling for applications to metabolite quantification. J Pharm Sci. 1995 Apr;84(4):393-8. PubMed PMID: 7629726. 3: Masurel D, Houghton PJ, Young CL, Wainer IW. Efficacy, toxicity, pharmacokinetics, and in vitro metabolism of the enantiomers of ifosfamide in mice. Cancer Res. 1990 Jan 15;50(2):252-5. PubMed PMID: 2295063.