Aleplasinin, also known as PAZ-417, is a selective inhibitor of PAI-1 under development for treatment of Alzheimer's disease. Plasminogen activator inhibitor-1 (PAI-1) is a key negative regulator of the fibrinolytic system. In animal studies, inhibition of PAI-1 activity prevents arterial and venous thrombosis, indicating that PAI-1 inhibitors may be used as a new class of antithrombotics.
MedKoo Cat#: 319882
Name: Aleplasinin
CAS#: 481629-87-2
Chemical Formula: C28H27NO3
Exact Mass: 425.1991
Molecular Weight: 425.53
Elemental Analysis: C, 79.03; H, 6.40; N, 3.29; O, 11.28
The following data is based on the product molecular weight 425.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
