TSPA | CAS# 403990-79-4 | ATF6α Translocation Inducer

MedKoo Cat#: 564213 | Name: TSPA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

TSPA is an ATF6α translocation inducer which effectively promotes ATF6α translocation into the nucleus and ameliorates glucose homeostasis on db/db mice.

Chemical Structure

TSPA

CAS#403990-79-4

Theoretical Analysis

MedKoo Cat#: 564213

Name: TSPA

CAS#: 403990-79-4

Chemical Formula: C29H27ClN6O3S

Exact Mass: 574.1554

Molecular Weight: 575.08

Elemental Analysis: C, 60.57; H, 4.73; Cl, 6.16; N, 14.61; O, 8.35; S, 5.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

TSPA

IUPAC/Chemical Name

2-[5-[1-(4-Chlorophenoxy)ethyl]-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide

InChi Key

PICTXBXMOXWNGL-UHFFFAOYSA-N

InChi Code

InChI=1S/C29H27ClN6O3S/c1-19-26(28(38)36(34(19)3)23-12-8-5-9-13-23)31-25(37)18-40-29-33-32-27(35(29)22-10-6-4-7-11-22)20(2)39-24-16-14-21(30)15-17-24/h4-17,20H,18H2,1-3H3,(H,31,37)

SMILES Code

O=C(NC1=C(C)N(C)N(C2=CC=CC=C2)C1=O)CSC3=NN=C(C(OC4=CC=C(Cl)C=C4)C)N3C5=CC=CC=C5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 575.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Zhou T, Cheng Y, Yan W, Shi X, Xu X, Zhou J, Li J, Chen J, Shen X. TSPA as a novel ATF6α translocation inducer efficiently ameliorates insulin sensitivity restoration and glucose homeostasis in db/db mice. Biochem Biophys Res Commun. 2018 May 23;499(4):948-953. doi: 10.1016/j.bbrc.2018.04.025. Epub 2018 Apr 9. PubMed PMID: 29626480.