Trypacidin | CAS#1900-29-4 | Fungal metabolite

MedKoo Cat#: 464014 | Name: Trypacidin

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trypacidin is a fungal metabolite originally isolated from A. fumigatus. It is active against B. subtilis and M. bovis, as well as T. cruzi and T. gondii. It reduces viability and induces lysis of A549 human lung cancer cells. Trypacidin increases survival in a mouse model of T. gondii infection when administered in six doses of 12.5 mg/kg each.

Chemical Structure

Trypacidin

CAS#1900-29-4

Theoretical Analysis

MedKoo Cat#: 464014

Name: Trypacidin

CAS#: 1900-29-4

Chemical Formula: C18H16O7

Exact Mass: 344.0896

Molecular Weight: 344.32

Elemental Analysis: C, 62.79; H, 4.68; O, 32.53

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 500.00	2 Weeks
5mg	USD 1,000.00	2 Weeks

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Related CAS #

No Data

Synonym

Trypacidin;

IUPAC/Chemical Name

methyl 4,6'-dimethoxy-6-methyl-3,4'-dioxo-3H-spiro[benzofuran-2,1'-cyclohexane]-2',5'-diene-2'-carboxylate

InChi Key

KMZYINVXZDQCKC-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H16O7/c1-9-5-12(22-2)15-13(6-9)25-18(16(15)20)11(17(21)24-4)7-10(19)8-14(18)23-3/h5-8H,1-4H3

SMILES Code

O=C1C2(OC3=CC(C)=CC(OC)=C13)C(C(OC)=O)=CC(C=C2OC)=O

Appearance

Solid powder

Purity

>95% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 344.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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PMID: 29745730. 4: Hagiwara D, Sakai K, Suzuki S, Umemura M, Nogawa T, Kato N, Osada H, Watanabe A, Kawamoto S, Gonoi T, Kamei K. Temperature during conidiation affects stress tolerance, pigmentation, and trypacidin accumulation in the conidia of the airborne pathogen Aspergillus fumigatus. PLoS One. 2017 May 9;12(5):e0177050. doi: 10.1371/journal.pone.0177050. PMID: 28486558; PMCID: PMC5423626. 5: Weber J, Valiante V, Nødvig CS, Mattern DJ, Slotkowski RA, Mortensen UH, Brakhage AA. Functional Reconstitution of a Fungal Natural Product Gene Cluster by Advanced Genome Editing. ACS Synth Biol. 2017 Jan 20;6(1):62-68. doi: 10.1021/acssynbio.6b00203. Epub 2016 Sep 13. PMID: 27611015. 6: Mattern DJ, Schoeler H, Weber J, Novohradská S, Kraibooj K, Dahse HM, Hillmann F, Valiante V, Figge MT, Brakhage AA. Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus. 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PLoS One. 2012;7(2):e29906. doi: 10.1371/journal.pone.0029906. Epub 2012 Feb 3. PMID: 22319557; PMCID: PMC3272003. 10: Frisvad JC, Rank C, Nielsen KF, Larsen TO. Metabolomics of Aspergillus fumigatus. Med Mycol. 2009;47 Suppl 1:S53-71. doi: 10.1080/13693780802307720. Epub 2008 Sep 1. PMID: 18763205. 11: Larsen TO, Smedsgaard J, Nielsen KF, Hansen MA, Samson RA, Frisvad JC. Production of mycotoxins by Aspergillus lentulus and other medically important and closely related species in section Fumigati. Med Mycol. 2007 May;45(3):225-32. doi: 10.1080/13693780601185939. PMID: 17464844. 12: Fischer G, Müller T, Schwalbe R, Ostrowski R, Dott W. Species-specific profiles of mycotoxins produced in cultures and associated with conidia of airborne fungi derived from biowaste. Int J Hyg Environ Health. 2000 Oct;203(2):105-16. doi: 10.1078/S1438-4639(04)70015-2. PMID: 11109562. 13: Fischer G, Müller T, Ostrowski R, Schwalbe R, Dott W. 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