Luminor 490RT | CAS#23749-58-8

MedKoo Cat#: 527980 | Name: Luminor-490RT

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Luminor 490RT, also known as Luminogren, also known as 7H-Benzimidazo(2,1-a)benz(de)isoquinolin-7-one, is a dye

Chemical Structure

Luminor-490RT

CAS#23749-58-8

Theoretical Analysis

MedKoo Cat#: 527980

Name: Luminor-490RT

CAS#: 23749-58-8

Chemical Formula: C18H10N2O

Exact Mass: 270.0793

Molecular Weight: 270.29

Elemental Analysis: C, 79.99; H, 3.73; N, 10.36; O, 5.92

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 350.00	2 Weeks

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Synonym

Luminofor Yellow-green 490RT; Luminogren; Luminophor 2; Luminor 2; Luminor Yellow Green 490RT; NSC 159457;

IUPAC/Chemical Name

7H-Benzimidazo(2,1-a)benz(de)isoquinolin-7-one

InChi Key

NZBSAAMEZYOGBA-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H10N2O/c21-18-13-8-4-6-11-5-3-7-12(16(11)13)17-19-14-9-1-2-10-15(14)20(17)18/h1-10H

SMILES Code

O=C(C1=CC=CC2=CC=CC3=C12)N4C3=NC5=CC=CC=C54

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

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Product Data

Product Data

Instruction

View handling instruction

Biological target:

Luminor 490RT, also known as Luminogren, also known as 7H-Benzimidazo(2,1-a)benz(de)isoquinolin-7-one, is a dye.

In vitro activity:

The fluorescence of TPE-CNC (luminogen tetraphenylethylene based fluorescent cellulose nanocrystals) aqueous suspensions is rapidly quenched (response time less than 10 s) due to the electron-transfer process between TPE and Fe3+ upon addition of Fe3+. TPE-CNCs have high sensitivity and selectivity toward Fe3+ over a broad pH range from 4 to 10. Reference: RSC Adv. 2022 Aug 30;12(38):24633-24639. https://pubmed.ncbi.nlm.nih.gov/36128393/

In vivo activity:

This study reports an aggregation-induced emission (AIE) dye-powered SP afterglow luminogen by leveraging on the unique characteristics of an AIE dye to circumvent the concentration-quenching effect, enhance afterglow intensity and prolong afterglow duration. The as-prepared luminogen shows good performance in in vivo tumour imaging in mice. Reference: Chem Sci. 2019 Nov 11;11(2):419-428. https://pubmed.ncbi.nlm.nih.gov/32190262/

Preparing Stock Solutions

The following data is based on the product molecular weight 270.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Ye X, Zhang D, Wang S, Zhou P, Zhu P. Fluorescent cellulose nanocrystals based on AIE luminogen for rapid detection of Fe3+ in aqueous solutions. RSC Adv. 2022 Aug 30;12(38):24633-24639. doi: 10.1039/d2ra04272j. PMID: 36128393; PMCID: PMC9426647. 2. Park H, Niu G, Wu C, Park C, Liu H, Park H, Kwok RTK, Zhang J, He B, Tang BZ. Precise and long-term tracking of mitochondria in neurons using a bioconjugatable and photostable AIE luminogen. Chem Sci. 2022 Feb 11;13(10):2965-2970. doi: 10.1039/d1sc06336g. PMID: 35382465; PMCID: PMC8905947. 3. Xu Y, Yang W, Yao D, Bian K, Zeng W, Liu K, Wang D, Zhang B. An aggregation-induced emission dye-powered afterglow luminogen for tumor imaging. Chem Sci. 2019 Nov 11;11(2):419-428. doi: 10.1039/c9sc04901k. PMID: 32190262; PMCID: PMC7067237. 4. Zhuang W, Ma B, Hu J, Jiang J, Li G, Yang L, Wang Y. Two-photon AIE luminogen labeled multifunctional polymeric micelles for theranostics. Theranostics. 2019 Aug 27;9(22):6618-6630. doi: 10.7150/thno.33901. PMID: 31588239; PMCID: PMC6771243.

In vitro protocol:

In vivo protocol:

1. Xu Y, Yang W, Yao D, Bian K, Zeng W, Liu K, Wang D, Zhang B. An aggregation-induced emission dye-powered afterglow luminogen for tumor imaging. Chem Sci. 2019 Nov 11;11(2):419-428. doi: 10.1039/c9sc04901k. PMID: 32190262; PMCID: PMC7067237. 2. Zhuang W, Ma B, Hu J, Jiang J, Li G, Yang L, Wang Y. Two-photon AIE luminogen labeled multifunctional polymeric micelles for theranostics. Theranostics. 2019 Aug 27;9(22):6618-6630. doi: 10.7150/thno.33901. PMID: 31588239; PMCID: PMC6771243.