MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 527975 | Name: Lumogallion
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lumogallion, also known as NSC 102798, is a bioactive chemical.

Chemical Structure

Lumogallion
Lumogallion
CAS#4386-25-8

Theoretical Analysis

MedKoo Cat#: 527975

Name: Lumogallion

CAS#: 4386-25-8

Chemical Formula: C12H9ClN2O6S

Exact Mass: 343.9870

Molecular Weight: 344.72

Elemental Analysis: C, 41.81; H, 2.63; Cl, 10.28; N, 8.13; O, 27.85; S, 9.30

Price and Availability

Size Price Availability Quantity
500mg USD 250.00 2 Weeks
1g USD 450.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Lumogallion; Lumogallion IREA; NSC 102798; NSC-102798; NSC102798;
IUPAC/Chemical Name
4-Chloro-3-(2,4-dihydroxyphenylazo)-2-hydroxybenzene-1-sulfonic acid
InChi Key
BTAABTQYJOGWEW-CCEZHUSRSA-N
InChi Code
InChI=1S/C12H9ClN2O6S/c13-7-2-4-10(22(19,20)21)12(18)11(7)15-14-8-3-1-6(16)5-9(8)17/h1-5,16-18H,(H,19,20,21)/b15-14+
SMILES Code
O=S(C1=CC=C(Cl)C(/N=N/C2=CC=C(O)C=C2O)=C1O)(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Lumogallion is a highly sensitive fluorescent reagent for the detection of aluminum, gallium and other metals.
In vitro activity:
Including micromolar concentrations of lumogallion in the culture medium resulted in a strong fluorescence signal from cells that had phagocytosed the aluminum adjuvant. Both aluminum oxyhydroxide and aluminum hydroxyphosphate, two of the most commonly used aluminum adjuvants in clinical vaccines, could be pre-stained with lumogallion and were easily tracked intracellularly after incubation with phagocytosing cells. Staining of viable cells using lumogallion will be a useful method in investigations of the mechanisms behind aluminum adjuvants' differentiation of antigen-presenting cells into inflammatory cells. Reference: J Immunol Methods. 2015 Jul;422:87-94. https://pubmed.ncbi.nlm.nih.gov/25896212/
In vivo activity:
In the current study, fluorescent lifetime imaging (FLIM) analysis was used to quantify Al(3+) uptake in the root-cell cytoplasm in vivo. This was performed via the estimation of the fluorescence lifetime of Al-lumogallion {5-chloro-3[(2,4-dihydroxyphenyl)azo]-2-hydroxybenzenesulfonic acid} complexes and measurements of intracellular pH while exposing arabidopsis seedlings to acidic and Al(3+) stresses. Reference: Ann Bot. 2009 Jul;104(1):189-95. https://pubmed.ncbi.nlm.nih.gov/19401291/
Solvent mg/mL mM
Solubility
DMF 10.0 29.01
DMSO 55.0 159.55
Ethanol 1.0 2.90
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 344.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Rony L, Pascaretti-Grizon F, Hubert L, Chappard D. Histochemical identification of wear debris released by alumina-on-alumina hip prostheses in the periprosthetic tissues. Orthop Traumatol Surg Res. 2021 Feb;107(1):102636. doi: 10.1016/j.otsr.2020.03.027. Epub 2020 Oct 3. PMID: 33023845. 2. Mile I, Svensson A, Darabi A, Mold M, Siesjö P, Eriksson H. Al adjuvants can be tracked in viable cells by lumogallion staining. J Immunol Methods. 2015 Jul;422:87-94. doi: 10.1016/j.jim.2015.04.008. Epub 2015 Apr 17. PMID: 25896212. 3. Babourina O, Rengel Z. Uptake of aluminium into Arabidopsis root cells measured by fluorescent lifetime imaging. Ann Bot. 2009 Jul;104(1):189-95. doi: 10.1093/aob/mcp098. Epub 2009 Apr 28. PMID: 19401291; PMCID: PMC2706735.
In vitro protocol:
1. Rony L, Pascaretti-Grizon F, Hubert L, Chappard D. Histochemical identification of wear debris released by alumina-on-alumina hip prostheses in the periprosthetic tissues. Orthop Traumatol Surg Res. 2021 Feb;107(1):102636. doi: 10.1016/j.otsr.2020.03.027. Epub 2020 Oct 3. PMID: 33023845. 2. Mile I, Svensson A, Darabi A, Mold M, Siesjö P, Eriksson H. Al adjuvants can be tracked in viable cells by lumogallion staining. J Immunol Methods. 2015 Jul;422:87-94. doi: 10.1016/j.jim.2015.04.008. Epub 2015 Apr 17. PMID: 25896212.
In vivo protocol:
1. Babourina O, Rengel Z. Uptake of aluminium into Arabidopsis root cells measured by fluorescent lifetime imaging. Ann Bot. 2009 Jul;104(1):189-95. doi: 10.1093/aob/mcp098. Epub 2009 Apr 28. PMID: 19401291; PMCID: PMC2706735.

View History

Navafenterol

Navafenterol