VU6001376 is a potent and selective mGlu4 PAMs. It has EC50 = 50.1 nM, 50.5% GluMax). It showed selective mGlu4 PAM with an excellent rat DMPK profile (in vivo rat CLp = 3.1 mL/min/kg, t1/2 = 445 min, CYP1A2 IC50 > 30 μM). VU6001376 was also active in reversing haloperidol induced catalepsy in a rodent preclinical model of Parkinson’s disease.
MedKoo Cat#: 555331
Name: VU6001376
CAS#: 1968546-34-0
Chemical Formula: C18H14F2N6OS
Exact Mass: 400.0918
Molecular Weight: 400.41
Elemental Analysis: C, 53.99; H, 3.52; F, 9.49; N, 20.99; O, 4.00; S, 8.01
The following data is based on the product molecular weight 400.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
