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MedKoo Cat#: 584607 | Name: Procyclidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Procyclidine is a muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.

Chemical Structure

Procyclidine
CAS#77-37-2

Theoretical Analysis

MedKoo Cat#: 584607

Name: Procyclidine

CAS#: 77-37-2

Chemical Formula: C19H29NO

Exact Mass: 287.2249

Molecular Weight: 287.45

Elemental Analysis: C, 79.39; H, 10.17; N, 4.87; O, 5.57

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Procyclidine
IUPAC/Chemical Name
1-Cyclohexyl-1-phenyl-3-(1-pyrrolidinyl)-1-propanol
InChi Key
WYDUSKDSKCASEF-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H29NO/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2
SMILES Code
OC(C1=CC=CC=C1)(C2CCCCC2)CCN3CCCC3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 287.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cho Y, Kim WS, Hur GH, Ha YC. Minimum effective drug concentrations of a transdermal patch system containing procyclidine and physostigmine for prophylaxis against soman poisoning in rhesus monkeys. Environ Toxicol Pharmacol. 2012 Jan;33(1):1-8. doi: 10.1016/j.etap.2011.10.002. Epub 2011 Oct 17. PubMed PMID: 22051905. 2: Myhrer T, Mariussen E, Enger S, Aas P. Capacities of metabotropic glutamate modulators in counteracting soman-induced seizures in rats. Eur J Pharmacol. 2013 Oct 15;718(1-3):253-60. doi: 10.1016/j.ejphar.2013.08.024. Epub 2013 Sep 7. PubMed PMID: 24021536. 3: Myhrer T, Aas P. Choice of approaches in developing novel medical countermeasures for nerve agent poisoning. Neurotoxicology. 2014 Sep;44:27-38. doi: 10.1016/j.neuro.2014.04.011. Epub 2014 May 9. Review. PubMed PMID: 24820435. 4: Bamrah JS, Kumar V, Krska J, Soni SD. Interactions between procyclidine and neuroleptic drugs. Some pharmacological and clinical aspects. Br J Psychiatry. 1986 Dec;149:726-33. PubMed PMID: 2878700. 5: Myhrer T, Enger S, Mariussen E, Aas P. Two medical therapies very effective shortly after high levels of soman poisoning in rats, but only one with universal utility. Toxicology. 2013 Dec 15;314(2-3):221-8. doi: 10.1016/j.tox.2013.08.005. Epub 2013 Aug 16. PubMed PMID: 23959147. 6: Sharma T, Galea A, Zachariah E, Das M, Taylor D, Ruprah M, Kumari V. Effects of 10 mg and 15 mg oral procyclidine on critical flicker fusion threshold and cardiac functioning in healthy human subjects. J Psychopharmacol. 2002 Jun;16(2):183-7. Erratum in: J Psychopharmacol. 2003 Mar;17(1):following table of contents. PubMed PMID: 12095079. 7: El-Haj B, Al-Amri A, Ali HS. Target urinary analytes for the gas chromatographic- mass spectrometric detection of procyclidine and benzhexol in drug abuse cases. J Anal Toxicol. 2011 Mar;35(2):92-8. PubMed PMID: 21396228. 8: Jevtovic-Todorovic V, Meyenburg AP, Olney JW, Wozniak DF. Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. Neuropharmacology. 2003 May;44(6):739-48. PubMed PMID: 12681372. 9: Kumari V, Zachariah E, Galea A, Jones HC, Das M, Mehrotra R, Taylor D, Sharma T. Effects of acute procyclidine administration on prepulse inhibition of the startle response in schizophrenia: a double-blind, placebo-controlled study. J Psychopharmacol. 2003 Mar;17(1):89-95. PubMed PMID: 12680744. 10: Myhrer T, Mariussen E, Enger S, Aas P. Supralethal poisoning by any of the classical nerve agents is effectively counteracted by procyclidine regimens in rats. Neurotoxicology. 2015 Sep;50:142-8. doi: 10.1016/j.neuro.2015.08.012. Epub 2015 Aug 28. PubMed PMID: 26318504. 11: Haug KH, Myhrer T, Fonnum F. The combination of donepezil and procyclidine protects against soman-induced seizures in rats. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):156-63. Epub 2007 Jan 3. PubMed PMID: 17289099. 12: Myhrer T, Enger S, Aas P. The perirhinal cortex of rats: an intricate area for microinfusion of anticonvulsants against soman-induced seizures. Neurotoxicology. 2013 Jan;34:128-34. doi: 10.1016/j.neuro.2012.10.019. Epub 2012 Nov 16. PubMed PMID: 23164931. 13: Whiteman PD, Fowle AS, Hamilton MJ, Peck AW, Bye A, Dean K, Webster A. Pharmacokinetics and Pharmacodynamics of procyclidine in man. Eur J Clin Pharmacol. 1985;28(1):73-8. PubMed PMID: 3987788. 14: Choi EK, Park D, Yon JM, Hur GH, Ha YC, Che JH, Kim J, Shin S, Jang JY, Hwang SY, Seong YH, Kim DJ, Kim JC, Kim YB. Protection by sustained release of physostigmine and procyclidine of soman poisoning in rats. Eur J Pharmacol. 2004 Nov 28;505(1-3):83-91. PubMed PMID: 15556140. 15: Joosen MJ, van der Schans MJ, Kuijpers WC, van Helden HP, Noort D. Timing of decontamination and treatment in case of percutaneous VX poisoning: a mini review. Chem Biol Interact. 2013 Mar 25;203(1):149-53. doi: 10.1016/j.cbi.2012.10.002. Epub 2012 Oct 16. Review. PubMed PMID: 23085122. 16: Kim WS, Cho Y, Kim JC, Huang ZZ, Park SH, Choi EK, Shin S, Nam SY, Kang JK, Hwang SY, Kim YB. Protection by a transdermal patch containing physostigmine and procyclidine of soman poisoning in dogs. Eur J Pharmacol. 2005 Nov 21;525(1-3):135-42. Epub 2005 Oct 27. PubMed PMID: 16256978. 17: Hadidi KA. Development of a screening method for the most commonly abused anticholinergic drugs in Jordan; trihexyphenidyl, procyclidine and biperiden. Leg Med (Tokyo). 2004 Oct;6(4):233-41. PubMed PMID: 15363448. 18: Rogiers V, Paeme G, Sonck W, Vercruysse A. Metabolism of procyclidine in isolated rat hepatocytes. Xenobiotica. 1987 Jul;17(7):849-57. PubMed PMID: 3660855. 19: Owen JA, Sribney M, Lawson JS, Delva N, Letemendia FJ. Capillary gas chromatography of trihexyphenidyl, procyclidine and cycrimine in biological fluids. J Chromatogr. 1989 Sep 29;494:135-42. PubMed PMID: 2573609. 20: Zarnowski T, Kleinrok Z, Turski WA, Czuczwar SJ. The NMDA antagonist procyclidine, but not ifenprodil, enhances the protective efficacy of common antiepileptics against maximal electroshock-induced seizures in mice. J Neural Transm Gen Sect. 1994;97(1):1-12. PubMed PMID: 7888145.