AD 5467 | CAS# 138333-32-1

MedKoo Cat#: 591053 | Name: AD 5467

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AD-5467 is a bioactive chemical.

Chemical Structure

AD 5467

CAS#138333-32-1

Theoretical Analysis

MedKoo Cat#: 591053

Name: AD 5467

CAS#: 138333-32-1

Chemical Formula: C16H21NO3S

Exact Mass: 307.1242

Molecular Weight: 307.41

Elemental Analysis: C, 62.51; H, 6.89; N, 4.56; O, 15.61; S, 10.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

AD 5467; AD5467; AD-5467

IUPAC/Chemical Name

2H-1,4-Benzoxazine-4-acetic acid, 3,4-dihydro-2,8-diisopropyl-3-thioxo-

InChi Key

CLDJCRWXLDLJLO-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H21NO3S/c1-9(2)11-6-5-7-12-15(11)20-14(10(3)4)16(21)17(12)8-13(18)19/h5-7,9-10,14H,8H2,1-4H3,(H,18,19)

SMILES Code

O=C(O)CN1C(C(C(C)C)OC2=C(C(C)C)C=CC=C12)=S

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 307.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Win T, Asano G, Shimizu Y. The efficacy of aldose reductase inhibitor, antioxidant butylated hydroxytoluene and cysteine protease inhibitor E64 on hyperglycemia-induced metabolic changes in the organ-cultured bovine lens. Nihon Ika Daigaku Zasshi. 1994 Jun;61(3):180-9. PubMed PMID: 8045992. 2: Chanalet L, Lapalus P. Drugs designed to maintain the transparence of the ocular lens. Fundam Clin Pharmacol. 1994;8(4):322-41. Review. PubMed PMID: 7851838. 3: Ohtori A, Yamamoto Y, Tojo KJ. Penetration and binding of aldose-reductase inhibitors in the lens. Invest Ophthalmol Vis Sci. 1991 Jan;32(1):189-93. PubMed PMID: 1898917. 4: Tawada H, Sugiyama Y, Ikeda H, Yamamoto Y, Meguro K. Studies on antidiabetic agents. IX. A new aldose reductase inhibitor, AD-5467, and related 1,4-benzoxazine and 1,4-benzothiazine derivatives: synthesis and biological activity. Chem Pharm Bull (Tokyo). 1990 May;38(5):1238-45. PubMed PMID: 2118427. 5: Yamamoto Y, Ohtori A. In vitro study of aldose reductase inhibitor concentrations in the lens and inhibitory effect on sugar alcohol accumulation. Curr Eye Res. 1990 May;9(5):421-8. PubMed PMID: 2116955.