MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 564113 | Name: AMG-1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AMG-1 is a specific CRAC channel inhibitor. AMG-1 blocks the function of effector T cells, but not regulatory T cells in vitro and it attenuates the progression and severity of EAE in vivo.

Chemical Structure

AMG-1
AMG-1
CAS#903591-53-7 (free base)

Theoretical Analysis

MedKoo Cat#: 564113

Name: AMG-1

CAS#: 903591-53-7 (free base)

Chemical Formula: C18H9ClF5N3O

Exact Mass: 413.0354

Molecular Weight: 413.73

Elemental Analysis: C, 52.26; H, 2.19; Cl, 8.57; F, 22.96; N, 10.16; O, 3.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
903591-53-7 (free base) 903591-56-0 (HCl)
Synonym
AMG1; AMG 1; AMG-1
IUPAC/Chemical Name
N-(5-(2-Chloro-5-(trifluoromethyl)phenyl)-2-pyrazinyl)-2,6-difluorobenzamide
InChi Key
LWJKSVUJZBEXCH-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H9ClF5N3O/c19-11-5-4-9(18(22,23)24)6-10(11)14-7-26-15(8-25-14)27-17(28)16-12(20)2-1-3-13(16)21/h1-8H,(H,26,27,28)
SMILES Code
O=C(NC1=NC=C(C2=CC(C(F)(F)F)=CC=C2Cl)N=C1)C3=C(F)C=CC=C3F
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 413.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li WP, Feng YP, Zhang JT. [Effect of AMG-1 on free intrasynaptosome calcium level and on the isolated artery contraction induced by norepinephrine]. Yao Xue Xue Bao. 1994;29(10):721-4. Chinese. PubMed PMID: 7871995. 2: Liu L, Feng YP. [Effect of AMG-1 and adenosine on glutamate release from synaptosomes in rats]. Yao Xue Xue Bao. 1993;28(12):881-5. Chinese. PubMed PMID: 8030410. 3: Liu L, Feng YP, Hu D, Li HS, Zhang JT. [Effects of AMG-1 on energy metabolism and neuronal damage of ischemic brain in mice and rats]. Yao Xue Xue Bao. 1991;26(12):881-5. Chinese. PubMed PMID: 1823985.