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MedKoo Cat#: 564104 | Name: Amthamine HBr
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Amthamine is a selective histamine H2 receptor agonist which does not stimulate activity of H1 and H3 receptors. Similar to histamine, Amthamine inhibits receptor -mediated eosinophil peroxidase. Amthamine has been shown to suppress the release of serotonin and has been used to study the involvement of H1 and H2 receptors on ion secretion.

Chemical Structure

Amthamine HBr
Amthamine HBr
CAS#142457-00-9 (HBr)

Theoretical Analysis

MedKoo Cat#: 564104

Name: Amthamine HBr

CAS#: 142457-00-9 (HBr)

Chemical Formula: C6H13Br2N3S

Exact Mass: 0.0000

Molecular Weight: 319.06

Elemental Analysis: C, 22.59; H, 4.11; Br, 50.09; N, 13.17; S, 10.05

Price and Availability

Size Price Availability Quantity
25mg USD 250.00 2 Weeks
50mg USD 450.00 2 Weeks
100mg USD 750.00 2 Weeks
200mg USD 1,250.00 2 Weeks
500mg USD 2,650.00 2 Weeks
1g USD 3,850.00 2 Weeks
2g USD 5,850.00 2 Weeks
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Related CAS #
142437-67-0 (free base) 142457-00-9 (HBr)
Synonym
Amthamine dihydrobromide; Amthamine di-hydrobromide
IUPAC/Chemical Name
5-(2-Aminoethyl)-4-methyl-1,3-thiazol-2-amine dihydrobromide
InChi Key
XFXNNOPUDSFVJE-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H11N3S.2BrH/c1-4-5(2-3-7)10-6(8)9-4;;/h2-3,7H2,1H3,(H2,8,9);2*1H
SMILES Code
NC1=NC(C)=C(CCN)S1.[H]Br.[H]Br
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 319.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PMID: 8377843. 5: Coruzzi G, Gambarelli E, Timmerman H. Cardiac effects of amthamine: a new histamine H2-receptor agonist. Eur J Clin Invest. 1995 Mar;25 Suppl 1:27-8. PMID: 7781673. 6: Poli E, Pozzoli C, Coruzzi G, Bertaccini G, Timmerman H. In vitro cardiac pharmacology of the new histamine H2-receptor agonist amthamine: comparisons with histamine and dimaprit. Agents Actions. 1993 Sep;40(1-2):44-9. doi: 10.1007/BF01976750. PMID: 8147269. 7: Coruzzi G, Pozzoli C, Poli E, Coppelli G, Bertaccini G. Effects of histamine H2 receptor agonists and antagonists on the isolated guinea pig gallbladder. Fundam Clin Pharmacol. 1999;13(1):84-90. doi: 10.1111/j.1472-8206.1999.tb00324.x. PMID: 10027092. 8: Szeberényi JB, Orsó E, László V, Falus A, Schmitz G. Histamine and H2 agonist amthamine increase oxidative burst activity of human leukocytes determined by flow cytometry. Inflamm Res. 2000 Apr;49 Suppl 1:S72-3. doi: 10.1007/PL00000191. PMID: 10864429. 9: Xu L, Lin W, Zheng Y, Chen J, Fang Z, Tan N, Hu W, Guo Y, Wang Y, Chen Z. An H2R-dependent medial septum histaminergic circuit mediates feeding behavior. Curr Biol. 2022 May 9;32(9):1937-1948.e5. doi: 10.1016/j.cub.2022.03.010. Epub 2022 Mar 25. PMID: 35338850. 10: Michinaga S, Sonoda K, Inazuki N, Ezaki M, Awane H, Shimizu K, Hishinuma S, Mizuguchi H. Selective histamine H2 receptor agonists alleviate blood-brain barrier disruption by promoting the expression of vascular protective factors following traumatic brain injury in mice. J Pharmacol Sci. 2022 Nov;150(3):135-145. doi: 10.1016/j.jphs.2022.08.003. Epub 2022 Aug 19. PMID: 36184118. 11: Rossbach K, Wahle K, Bruer G, Brehm R, Langeheine M, Rode K, Schaper- Gerhardt K, Gutzmer R, Werfel T, Kietzmann M, Bäumer W. Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis. Acta Derm Venereol. 2020 Dec 9;100(19):adv00342. doi: 10.2340/00015555-3674. PMID: 33104231; PMCID: PMC9309706. 12: van der Goot H, Timmerman H. Selective ligands as tools to study histamine receptors. Eur J Med Chem. 2000 Jan;35(1):5-20. doi: 10.1016/s0223-5234(00)00101-x. PMID: 10733599. 13: Alonso N, Zappia CD, Cabrera M, Davio CA, Shayo C, Monczor F, Fernández NC. Physiological implications of biased signaling at histamine H2 receptors. Front Pharmacol. 2015 Mar 10;6:45. doi: 10.3389/fphar.2015.00045. PMID: 25805997; PMCID: PMC4354273. 14: Fernandez N, Monczor F, Baldi A, Davio C, Shayo C. Histamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization. Mol Pharmacol. 2008 Oct;74(4):1109-18. doi: 10.1124/mol.108.045336. Epub 2008 Jul 10. PMID: 18617631. 15: Alonso N, Diaz Nebreda A, Monczor F, Gutkind JS, Davio C, Fernandez N, Shayo C. PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells. Biochim Biophys Acta. 2016 Sep;1860(9):1998-2007. doi: 10.1016/j.bbagen.2016.06.016. Epub 2016 Jun 15. PMID: 27316323. 16: Lee HJ, Park MK, Lee EJ, Kim YL, Kim HJ, Kang JH, Kim HM, Lee AY, Lee CH. Histamine receptor 2-mediated growth-differentiation factor-15 expression is involved in histamine-induced melanogenesis. Int J Biochem Cell Biol. 2012 Dec;44(12):2124-8. doi: 10.1016/j.biocel.2012.08.020. Epub 2012 Sep 2. PMID: 22975449. 17: Bugajski J, Gadek-Michalska A, Bugajski AJ. Nitric oxide and prostaglandin systems in the stimulation of hypothalamic-pituitary-adrenal axis by neurotransmitters and neurohormones. J Physiol Pharmacol. 2004 Dec;55(4):679-703. PMID: 15613736. 18: Verma L, Agrawal D, Jain NS. Enhanced central histaminergic transmission attenuates compulsive-like behavior in mice. Neuropharmacology. 2018 Aug;138:106-117. doi: 10.1016/j.neuropharm.2018.05.031. Epub 2018 May 25. PMID: 29885535. 19: Gergs U, Bernhardt G, Buchwalow IB, Edler H, Fröba J, Keller M, Kirchhefer U, Köhler F, Mißlinger N, Wache H, Neumann J. Initial Characterization of Transgenic Mice Overexpressing Human Histamine H2 Receptors. J Pharmacol Exp Ther. 2019 Apr;369(1):129-141. doi: 10.1124/jpet.118.255711. Epub 2019 Feb 6. PMID: 30728249. 20: Bugajski AJ, Koprowska B, Thor P, Głod R, Bugajski J. Involvement of nitric oxide in central histaminergic stimulation of the hypothalamic-pituitary-adrenal axis. J Physiol Pharmacol. 2000 Dec;51(4 Pt 2):907-15. PMID: 11220498.