Bromfenac Sodium Sesquihydrate | CAS# 120638-55-3 | NSAID, COX-2 Inhibitor

MedKoo Cat#: 564080 | Name: Bromfenac Sodium Sesquihydrate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bromfenac Sodium Sesquihydrate is a nonsteroidal anti-inflammatory drug (NSAID), which inhibits cyclooxygenase II (COX-2).

Chemical Structure

Bromfenac Sodium Sesquihydrate

CAS#120638-55-3 (sodium hydrate)

Theoretical Analysis

MedKoo Cat#: 564080

Name: Bromfenac Sodium Sesquihydrate

CAS#: 120638-55-3 (sodium hydrate)

Chemical Formula: C30H28Br2N2Na2O9

Exact Mass: 0.0000

Molecular Weight: 766.35

Elemental Analysis: C, 47.02; H, 3.68; Br, 20.85; N, 3.66; Na, 6.00; O, 18.79

Price and Availability

Size	Price	Availability
250mg	USD 350.00	2 Weeks
500mg	USD 550.00	2 Weeks
1g	USD 850.00	2 Weeks

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Related CAS #

91714-94-2 (free base) 91714-93-1 (sodium) 120638-55-3 (sodium hydrate)

Synonym

Bromfenac Sodium Sesquihydrate; AHR 10282B; AHR10282B; AHR-10282B

IUPAC/Chemical Name

Disodium 2-[2-amino-3-(4-bromobenzoyl)phenyl]acetate trihydrate

InChi Key

PPOSVVJOVKVBPW-UHFFFAOYSA-L

InChi Code

InChI=1S/2C15H12BrNO3.2Na.3H2O/c2*16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19;;;;;/h2*1-7H,8,17H2,(H,18,19);;;3*1H2/q;;2*+1;;;/p-2

SMILES Code

O=C([O-])CC1=CC=CC(C(C2=CC=C(Br)C=C2)=O)=C1N.O=C([O-])CC3=CC=CC(C(C4=CC=C(Br)C=C4)=O)=C3N.[H]O[H].[H]O[H].[H]O[H].[Na+].[Na+]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 766.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Carreño E, Portero A, Galarreta DJ, Herreras JM. Update on twice-daily bromfenac sodium sesquihydrate to treat postoperative ocular inflammation following cataract extraction. Clin Ophthalmol. 2012;6:637-44. doi: 10.2147/OPTH.S23381. Epub 2012 Apr 27. PubMed PMID: 22570544; PubMed Central PMCID: PMC3346189. 2: Kashiwagi K, Tsukahara S. Effect of non-steroidal anti-inflammatory ophthalmic solution on intraocular pressure reduction by latanoprost. Br J Ophthalmol. 2003 Mar;87(3):297-301. PubMed PMID: 12598441; PubMed Central PMCID: PMC1771533. 3: Nolan JC, Osman MA, Cheng LK, Sancilio LF. Bromfenac, a new nonsteroidal anti-inflammatory drug: relationship between the anti-inflammatory and analgesic activity and plasma drug levels in rodents. J Pharmacol Exp Ther. 1990 Jul;254(1):104-8. PubMed PMID: 2366177. 4: Nolan JC, Wagner LE, Gathright CE, Stephens DJ, Sancilio LF. The topical anti-inflammatory and analgesic properties of bromfenac in rodents. Agents Actions. 1988 Aug;25(1-2):77-85. PubMed PMID: 3189047. 5: Sancilio LF, Nolan JC, Wagner LE, Ward JW. The analgesic and antiinflammatory activity and pharmacologic properties of bromfenac. Arzneimittelforschung. 1987 May;37(5):513-9. PubMed PMID: 3497637.