JRC-II-191 | CD4-gp120 Inhibitor

MedKoo Cat#: 564016 | Name: JRC-II-191

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JRC-II-191 is an inhibitor of CD4-gp120 binding, blocking the binding of the HIV-1 envelope glycoprotein gp120 to the CD4 receptor.

Chemical Structure

JRC-II-191

CAS#NONE

Theoretical Analysis

MedKoo Cat#: 564016

Name: JRC-II-191

CAS#: NONE

Chemical Formula: C17H23ClFN3O2

Exact Mass: 355.1463

Molecular Weight: 355.84

Elemental Analysis: C, 57.38; H, 6.52; Cl, 9.96; F, 5.34; N, 11.81; O, 8.99

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JRC-II-191; JRCII191; JRC II 191; JRCII-191; JRC-II191; JRC II-191; JRC-II 191

IUPAC/Chemical Name

N-(4-Chloro-3-fluoro-phenyl)-N'-(2,2,6,6-tetramethyl-piperidin-4-yl)-oxalamide

InChi Key

WNIRIUAQGASKHI-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H23ClFN3O2/c1-16(2)8-11(9-17(3,4)22-16)21-15(24)14(23)20-10-5-6-12(18)13(19)7-10/h5-7,11,22H,8-9H2,1-4H3,(H,20,23)(H,21,24)

SMILES Code

O=C(NC1=CC=C(Cl)C(F)=C1)C(NC2CC(C)(C)NC(C)(C)C2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 355.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lalonde JM, Elban MA, Courter JR, Sugawara A, Soeta T, Madani N, Princiotto AM, Kwon YD, Kwong PD, Schön A, Freire E, Sodroski J, Smith AB 3rd. Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening. Bioorg Med Chem. 2011 Jan 1;19(1):91-101. doi: 10.1016/j.bmc.2010.11.049. Epub 2010 Nov 26. PubMed PMID: 21169023; PubMed Central PMCID: PMC3049263. 2: Haim H, Si Z, Madani N, Wang L, Courter JR, Princiotto A, Kassa A, DeGrace M, McGee-Estrada K, Mefford M, Gabuzda D, Smith AB 3rd, Sodroski J. Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state. PLoS Pathog. 2009 Apr;5(4):e1000360. doi: 10.1371/journal.ppat.1000360. Epub 2009 Apr 3. PubMed PMID: 19343205; PubMed Central PMCID: PMC2655723.