AZD8797 | CAS#911715-90-7 | CX3CL1 modulator

MedKoo Cat#: 561736 | Name: AZD8797

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZD8797 is a non-competitive allosteric modulator of CX3CL1. It acts by binding CX3CR1 and effecting G-protein signalling and ß-arrestin recruitment in a biased way.

Chemical Structure

AZD8797

CAS#911715-90-7

Theoretical Analysis

MedKoo Cat#: 561736

Name: AZD8797

CAS#: 911715-90-7

Chemical Formula: C19H25N5OS2

Exact Mass: 403.1501

Molecular Weight: 403.56

Elemental Analysis: C, 56.55; H, 6.24; N, 17.35; O, 3.96; S, 15.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

AZD8797; AZD-8797; AZD 8797;

IUPAC/Chemical Name

2(R)-[2-Amino-5-(1(S)-phenyl-ethylsulfanyl)-thiazolo[4,5-d]pyrimidin-7-ylamino]-4-methyl-pentan-1-ol

InChi Key

ZMQSLMZOWVGBSM-GXTWGEPZSA-N

InChi Code

InChI=1S/C19H25N5OS2/c1-11(2)9-14(10-25)21-16-15-17(22-18(20)27-15)24-19(23-16)26-12(3)13-7-5-4-6-8-13/h4-8,11-12,14,25H,9-10H2,1-3H3,(H3,20,21,22,23,24)/t12-,14+/m0/s1

SMILES Code

CC(C)C[C@@H](NC1=C(SC(N)=N2)C2=NC(S[C@H](C3=CC=CC=C3)C)=N1)CO

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 403.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Cederblad L, Rosengren B, Ryberg E, Hermansson NO. AZD8797 is an allosteric non-competitive modulator of the human CX3CR1 receptor. Biochem J. 2016 Mar 1;473(5):641-9. doi: 10.1042/BJ20150520. Epub 2015 Dec 11. PubMed PMID: 26656484; PubMed Central PMCID: PMC4764977. 2: Ridderstad Wollberg A, Ericsson-Dahlstrand A, Juréus A, Ekerot P, Simon S, Nilsson M, Wiklund SJ, Berg AL, Ferm M, Sunnemark D, Johansson R. Pharmacological inhibition of the chemokine receptor CX3CR1 attenuates disease in a chronic-relapsing rat model for multiple sclerosis. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5409-14. doi: 10.1073/pnas.1316510111. Epub 2014 Mar 25. PubMed PMID: 24706865; PubMed Central PMCID: PMC3986185. 3: Karlström S, Nordvall G, Sohn D, Hettman A, Turek D, Åhlin K, Kers A, Claesson M, Slivo C, Lo-Alfredsson Y, Petersson C, Bessidskaia G, Svensson PH, Rein T, Jerning E, Malmberg Å, Ahlgen C, Ray C, Vares L, Ivanov V, Johansson R. Substituted 7-amino-5-thio-thiazolo[4,5-d]pyrimidines as potent and selective antagonists of the fractalkine receptor (CX3CR1). J Med Chem. 2013 Apr 25;56(8):3177-90. doi: 10.1021/jm3012273. Epub 2013 Apr 4. PubMed PMID: 23516963.